5WJ6

Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004)

Summary for 5WJ6

• Entry DOI: 10.2210/pdb5wj6/pdb
• Related: 5FI6
• Descriptor: Glutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, ... (4 entities in total)
• Functional Keywords: glutaminase c, inhibitor, complex, glutamine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 238773.42

Authors

Huang, Q.,Cerione, R.A. (deposition date: 2017-07-21, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Huang, Q.,Stalnecker, C.,Zhang, C.,McDermott, L.A.,Iyer, P.,O'Neill, J.,Reimer, S.,Cerione, R.A.,Katt, W.P.; Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.; J. Biol. Chem., 293:3535-3545, 2018; PubMed: 29317493; DOI: 10.1074/jbc.M117.810101

Experimental method

X-RAY DIFFRACTION (2.445 Å)