6A5H
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7WF9
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6J15
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![BU of 6j15 by Molmil](/molmil-images/mine/6j15) | Complex structure of GY-5 Fab and PD-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ... | Authors: | Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | Deposit date: | 2018-12-27 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience, 14, 2019
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7DW5
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![BU of 7dw5 by Molmil](/molmil-images/mine/7dw5) | Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites | Descriptor: | BROMIDE ION, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), Double homeobox protein 4-like protein 2 | Authors: | Zhang, H, Cheng, N, Li, Z, Zhang, W, Dong, X, Huang, J, Meng, G. | Deposit date: | 2021-01-15 | Release date: | 2021-11-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia. Cancer Commun (Lond), 41, 2021
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6A4X
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![BU of 6a4x by Molmil](/molmil-images/mine/6a4x) | Oxidase ChaP-H2 | Descriptor: | Bleomycin resistance protein, FE (II) ION | Authors: | Zhang, B, Wang, Y.S, Ge, H.M. | Deposit date: | 2018-06-21 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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6A4Z
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![BU of 6a4z by Molmil](/molmil-images/mine/6a4z) | Oxidase ChaP | Descriptor: | ChaP protein, FE (II) ION | Authors: | Zhang, B, Ge, H.M. | Deposit date: | 2018-06-21 | Release date: | 2018-08-29 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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6A5G
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6LY4
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![BU of 6ly4 by Molmil](/molmil-images/mine/6ly4) | The crystal structure of the BM3 mutant LG-23 in complex with testosterone | Descriptor: | 1,2-ETHANEDIOL, Bifunctional cytochrome P450/NADPH--P450 reductase, IMIDAZOLE, ... | Authors: | Peng, Y, Chen, J, Zhou, J, Li, A, ReetZ, M.T. | Deposit date: | 2020-02-13 | Release date: | 2020-04-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants. Angew.Chem.Int.Ed.Engl., 59, 2020
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3SE8
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![BU of 3se8 by Molmil](/molmil-images/mine/3se8) | Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kwong, P.D, Zhou, T. | Deposit date: | 2011-06-10 | Release date: | 2011-08-10 | Last modified: | 2021-04-07 | Method: | X-RAY DIFFRACTION (1.895 Å) | Cite: | Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science, 333, 2011
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7WNH
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![BU of 7wnh by Molmil](/molmil-images/mine/7wnh) | Crystal structure of Nurr1 binding to NBRE | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*AP*AP*AP*GP*GP*TP*CP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*GP*AP*CP*CP*TP*TP*TP*TP*CP*GP*G)-3'), Nuclear receptor subfamily 4 group A member 2, ... | Authors: | Zhao, M, Xu, T, Wang, N, Guo, Y, Liu, J. | Deposit date: | 2022-01-18 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer. Proc.Natl.Acad.Sci.USA, 119, 2022
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5QJ1
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5QJ0
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6KV2
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7XAB
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![BU of 7xab by Molmil](/molmil-images/mine/7xab) | Crystal structure of PDE4D catalytic domain complexed with compound 22d | Descriptor: | 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | Authors: | Huang, Y.-Y, He, X, Luo, H.-B. | Deposit date: | 2022-03-17 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.00067449 Å) | Cite: | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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7XAA
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![BU of 7xaa by Molmil](/molmil-images/mine/7xaa) | Crystal structure of PDE4D catalytic domain complexed with compound 21d | Descriptor: | 8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | Authors: | Huang, Y.-Y, He, X, Luo, H.-B. | Deposit date: | 2022-03-17 | Release date: | 2023-02-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.100414 Å) | Cite: | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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5VO0
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![BU of 5vo0 by Molmil](/molmil-images/mine/5vo0) | Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
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5VNZ
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![BU of 5vnz by Molmil](/molmil-images/mine/5vnz) | Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | TNF receptor-associated factor 6, Ubiquitin, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
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4JPW
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![BU of 4jpw by Molmil](/molmil-images/mine/4jpw) | Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ... | Authors: | Acharya, P, Luongo, T, Zhou, T, Kwong, P.D. | Deposit date: | 2013-03-19 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.904 Å) | Cite: | Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell(Cambridge,Mass.), 153, 2013
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8KEE
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![BU of 8kee by Molmil](/molmil-images/mine/8kee) | Cyanophage A-1(L) sheath-tube | Descriptor: | sheath, tube | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KEA
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![BU of 8kea by Molmil](/molmil-images/mine/8kea) | Cyanophage A-1(L) baseplate-initiators | Descriptor: | baseplate gp16, central spike, hub, ... | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KE9
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8KEC
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![BU of 8kec by Molmil](/molmil-images/mine/8kec) | Cyanophage A-1(L) tail fiber | Descriptor: | Long tail fiber, short tail fiber | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KEF
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8KEG
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5YC4
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![BU of 5yc4 by Molmil](/molmil-images/mine/5yc4) | |