9UHT
 
 | | SARS-CoV-2 E-RTC in complex with RNA-nsp9 and GMPPNP | | Descriptor: | Helicase nsp13, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Huang, Y.C, Liu, Y.X, Lou, Z.Y, Rao, Z.H, Yan, L.M. | | Deposit date: | 2025-04-14 | | Release date: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Response to Matter Arising: Substrate selection and transition state support the mechanism for GTP-mediate RNA capping catalyzed by SARS-CoV-2 NiRAN
To Be Published
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2HKY
 | | NMR solution structure of human RNase 7 | | Descriptor: | Ribonuclease 7 | | Authors: | Huang, Y.-C, Chen, C, Lou, Y.-C. | | Deposit date: | 2006-07-06 | | Release date: | 2006-12-26 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.
J.Biol.Chem., 282, 2007
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9L09
 | | SARS-CoV-2 C-RTC with 13-TP | | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Huang, Y.C, Liang, L, Liu, Y.X, Yan, L.M, Lou, Z.Y, Rao, Z.H. | | Deposit date: | 2024-12-12 | | Release date: | 2025-03-19 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Discovery of a 2'-a-Fluoro-2'-b-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent
J Med Chem, 68, 2025
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6ZFO
 | | Association of two complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ... | | Authors: | Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-17 | | Release date: | 2020-07-08 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6ZDH
 | | SARS-CoV-2 Spike glycoprotein in complex with a neutralizing antibody EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, ... | | Authors: | Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-14 | | Release date: | 2020-07-01 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6ZDG
 | | Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ... | | Authors: | Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-14 | | Release date: | 2020-07-29 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6ZER
 | | Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ... | | Authors: | Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-16 | | Release date: | 2020-06-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6ZCZ
 | | Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in ternary complex with EY6A Fab and a nanobody. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EY6A heavy chain, ... | | Authors: | Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-12 | | Release date: | 2020-06-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6Z3P
 | | Structure of EV71 in complex with a protective antibody 38-3-11A Fab | | Descriptor: | SPHINGOSINE, VP1, VP2, ... | | Authors: | Zhou, D, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71.
Nat Commun, 11, 2020
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6Z3Q
 | | Structure of EV71 in complex with a protective antibody 38-1-10A Fab | | Descriptor: | Heavy chain, Light chain, SPHINGOSINE, ... | | Authors: | Zhou, D, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-05-21 | | Release date: | 2020-09-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71.
Nat Commun, 11, 2020
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6Z3K
 | | Structure of protective antibody 38-1-10A Fab | | Descriptor: | 1,2-ETHANEDIOL, Heavy chain, Light Chain | | Authors: | Zhou, D, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-05-20 | | Release date: | 2020-09-02 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71.
Nat Commun, 11, 2020
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5XMJ
 | | Crystal structure of quinol:fumarate reductase from Desulfovibrio gigas | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | | Authors: | Guan, H.H, Hsieh, Y.C, Lin, P.R, Chen, C.J. | | Deposit date: | 2017-05-15 | | Release date: | 2018-06-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas.
Sci Rep, 8, 2018
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2QN5
 | | Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin | | Descriptor: | Bowman-Birk type bran trypsin inhibitor, Cationic trypsin | | Authors: | Li, H.T, Lin, Y.H, Guan, H.H, Hsieh, Y.C, Wang, A.H.J, Chen, C.J. | | Deposit date: | 2007-07-18 | | Release date: | 2008-07-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure and Functional Study of the Bowman-Birk Inhibitor from Rice Bran in Complex with Bovine Trypsin
To be Published
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8W4L
 | | Crystal structure of closed conformation of human immunoglobulin Fc in presence of EndoSz | | Descriptor: | CHLORIDE ION, Immunoglobulin gamma-1 heavy chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4M
 | | Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz | | Descriptor: | Immunoglobulin gamma-1 heavy chain, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4G
 | | Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105 | | Descriptor: | CALCIUM ION, glycoside hydrolase | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4N
 | | Crystal structure of EndoSz mutant D234M, in space group P21, in complex with oligosaccharide G2S1 | | Descriptor: | CALCIUM ION, Glycoside hydrolase, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4I
 | | Crystal structure of EndoSz mutant D234M in space group P21 | | Descriptor: | CALCIUM ION, glycoside hydrolase | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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3LDK
 | | Crystal Structure of A. japonicus CB05 | | Descriptor: | Fructosyltransferase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Chuankhayan, P, Chen, C.J, Chaing, C.M, Hsieh, C.Y, Chen, C.D, Hsieh, Y.C. | | Deposit date: | 2010-01-13 | | Release date: | 2010-05-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of Aspergillus japonicus fructosyltransferase complex with donor/acceptor substrates reveal complete sbusites in the active site for catalysis
To be Published
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9ISC
 | | Human MTHFD2 in complex with compound 16a | | Descriptor: | (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-17 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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9IS9
 | | human MTHFD2 in complex with LY374571 | | Descriptor: | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-17 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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9IT3
 | | Human MTHFD2 in complex with compound 16e | | Descriptor: | (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-chloranyl-phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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9IUO
 | | Human MTHFD1 in complex with compound 16d | | Descriptor: | (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-methyl-phenyl]carbonylamino]pentanedioic acid, C-1-tetrahydrofolate synthase, cytoplasmic, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-22 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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9IT6
 | | Human MTHFD2 in complex with compound 16g | | Descriptor: | (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-chloranyl-phenyl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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9ISL
 | | Human MTHFD1 in complex with compound 16e | | Descriptor: | (2~{S})-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-5-yl]carbamoylamino]-3-chloranyl-phenyl]carbonylamino]pentanedioic acid, C-1-tetrahydrofolate synthase, cytoplasmic, ... | | Authors: | Lee, L.C, Wu, S.Y. | | Deposit date: | 2024-07-18 | | Release date: | 2025-01-01 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
J.Med.Chem., 67, 2024
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