8W4M

Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz

Summary for 8W4M

• Entry DOI: 10.2210/pdb8w4m/pdb
• Related: 8W4L
• Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• Functional Keywords: n-linked glycan, glycoside hydrolase, transglycosylation, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27409.08

Authors

Guan, H.H.,Lin, C.C.,Hsieh, Y.C.,Chen, C.J. (deposition date: 2023-08-24, release date: 2024-07-03)

• Primary citation: Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J.; Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism; Jacs Au, 4:2130-2150, 2024; DOI: 10.1021/jacsau.4c00004

Experimental method

X-RAY DIFFRACTION (2.18 Å)