5A0B
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![BU of 5a0b by Molmil](/molmil-images/mine/5a0b) | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | Descriptor: | (4R)-4-(4-cyanophenyl)-6-methyl-2-oxidanylidene-3-[2-oxidanylidene-2-(4-propan-2-ylpiperazin-1-yl)ethyl]-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | Deposit date: | 2015-04-17 | Release date: | 2015-08-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
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5A8Z
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![BU of 5a8z by Molmil](/molmil-images/mine/5a8z) | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(4R)-7-methyl-2,5-bis(oxidanylidene)-1-[3-(trifluoromethyl)phenyl]-3,4,6,8-tetrahydropyrimido[4,5-d]pyridazin-4-yl]benzenecarbonitrile, Neutrophil elastase, ... | Authors: | von Nussbaum, F, Li, V.M, Meibom, D, Anlauf, S, Bechem, M, Delbeck, M, Gerisch, M, Harrenga, A, Karthaus, D, Lang, D, Lustig, K, Mittendorf, J, Schaefer, M, Schaefer, S, Schamberger, J. | Deposit date: | 2015-07-17 | Release date: | 2016-08-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model. ChemMedChem, 11, 2016
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1E7J
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![BU of 1e7j by Molmil](/molmil-images/mine/1e7j) | HMG-D complexed to a bulge DNA | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*AP*TP*TP*AP*AP*GP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*CP*AP*AP*TP*AP*TP*CP*G)-3'), HIGH MOBILITY GROUP PROTEIN D | Authors: | Cerdan, R, Payet, D, Yang, J.-C, Travers, A.A, Neuhaus, D. | Deposit date: | 2000-08-29 | Release date: | 2001-03-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Hmg-D Complexed to a Bulge DNA: An NMR Model Protein Sci., 10, 2001
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1AUD
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![BU of 1aud by Molmil](/molmil-images/mine/1aud) | U1A-UTRRNA, NMR, 31 STRUCTURES | Descriptor: | RNA 3UTR, U1A 102 | Authors: | Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G. | Deposit date: | 1997-08-22 | Release date: | 1998-02-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis of the RNA-binding specificity of human U1A protein. EMBO J., 16, 1997
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2YOA
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![BU of 2yoa by Molmil](/molmil-images/mine/2yoa) | Synaptotagmin-1 C2B domain with phosphoserine | Descriptor: | CALCIUM ION, PHOSPHOSERINE, SYNAPTOTAGMIN-1, ... | Authors: | Honigmann, A, van den Bogaart, G, Iraheta, E, Risselada, H.J, Milovanovic, D, Mueller, V, Muellar, S, Diederichsen, U, Fasshauer, D, Grubmuller, H, Hell, S.W, Eggeling, C, Kuhnel, K, Jahn, R. | Deposit date: | 2012-10-22 | Release date: | 2013-03-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phosphatidylinositol 4,5-Bisphosphate Clusters Act as Molecular Beacons for Vesicle Recruitment Nat.Struct.Mol.Biol., 20, 2013
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2VRD
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![BU of 2vrd by Molmil](/molmil-images/mine/2vrd) | THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C | Descriptor: | U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C, ZINC ION | Authors: | Muto, Y, Pomeranz-Krummel, D, Oubridge, C, Hernandez, H, Robinson, C, Neuhaus, D, Nagai, K. | Deposit date: | 2008-03-31 | Release date: | 2008-04-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Structure and Biochemical Properties of the Human Spliceosomal Protein U1C J.Mol.Biol., 341, 2004
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1CDQ
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![BU of 1cdq by Molmil](/molmil-images/mine/1cdq) | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | Descriptor: | CD59 | Authors: | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | Deposit date: | 1994-06-01 | Release date: | 1994-09-30 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure, 2, 1994
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1CDR
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![BU of 1cdr by Molmil](/molmil-images/mine/1cdr) | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 | Authors: | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | Deposit date: | 1994-06-01 | Release date: | 1994-09-30 | Last modified: | 2020-07-29 | Method: | SOLUTION NMR | Cite: | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure, 2, 1994
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1CDS
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![BU of 1cds by Molmil](/molmil-images/mine/1cds) | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 | Authors: | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | Deposit date: | 1994-06-01 | Release date: | 1994-09-30 | Last modified: | 2020-07-29 | Method: | SOLUTION NMR | Cite: | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure, 2, 1994
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1SP7
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![BU of 1sp7 by Molmil](/molmil-images/mine/1sp7) | Structure of the Cys-rich C-terminal domain of Hydra minicollagen | Descriptor: | mini-collagen | Authors: | Meier, S, Haussinger, D, Pokidysheva, E, Bachinger, H.P, Grzesiek, S. | Deposit date: | 2004-03-16 | Release date: | 2004-05-18 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation. Febs Lett., 569, 2004
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2LBM
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![BU of 2lbm by Molmil](/molmil-images/mine/2lbm) | |
7BBD
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![BU of 7bbd by Molmil](/molmil-images/mine/7bbd) | Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2 | Descriptor: | Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Kiss, L, Neuhaus, D, James, L.C. | Deposit date: | 2020-12-17 | Release date: | 2021-01-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination. Nat Commun, 12, 2021
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7BBF
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![BU of 7bbf by Molmil](/molmil-images/mine/7bbf) | |
2BN5
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![BU of 2bn5 by Molmil](/molmil-images/mine/2bn5) | P-Element Somatic Inhibitor Protein Complex with U1-70k proline-rich peptide | Descriptor: | PSI, U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA | Authors: | Ignjatovic, T, Yang, J.-C, Butler, P.J.G, Neuhaus, D, Nagai, K. | Deposit date: | 2005-03-21 | Release date: | 2005-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of the Interaction between P-Element Somatic Inhibitor and U1-70K Essential for the Alternative Splicing of P-Element Transposase. J.Mol.Biol., 351, 2005
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2BN6
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![BU of 2bn6 by Molmil](/molmil-images/mine/2bn6) | P-Element Somatic Inhibitor Protein | Descriptor: | PSI | Authors: | Ignjatovic, T, Yang, J.C, Butler, P.J.G, Neuhaus, D, Nagai, K. | Deposit date: | 2005-03-21 | Release date: | 2005-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of the Interaction between P-Element Somatic Inhibitor and U1-70K Essential for the Alternative Splicing of P-Element Transposase. J.Mol.Biol., 351, 2005
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2NPS
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![BU of 2nps by Molmil](/molmil-images/mine/2nps) | Crystal Structure of the Early Endosomal SNARE Complex | Descriptor: | Syntaxin 13, Syntaxin-6, Vesicle transport through interaction with t-SNAREs homolog 1A, ... | Authors: | Zwilling, D, Cypionka, A, Pohl, W.H, Fasshauer, D, Walla, P.J, Wahl, M.C, Jahn, R. | Deposit date: | 2006-10-30 | Release date: | 2006-12-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies Embo J., 26, 2007
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2BO5
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![BU of 2bo5 by Molmil](/molmil-images/mine/2bo5) | Bovine oligomycin sensitivity conferral protein N-terminal domain | Descriptor: | ATP SYNTHASE OLIGOMYCIN SENSITIVITY CONFERRAL PROTEIN | Authors: | Carbajo, R.J, Kellas, F.A, Runswick, M.J, Montgomery, M.G, Walker, J.E, Neuhaus, D. | Deposit date: | 2005-04-07 | Release date: | 2005-08-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit. J. Mol. Biol., 351, 2005
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6AT9
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![BU of 6at9 by Molmil](/molmil-images/mine/6at9) | Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101 | Descriptor: | ALK, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2017-08-28 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9503 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
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1HMA
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![BU of 1hma by Molmil](/molmil-images/mine/1hma) | THE SOLUTION STRUCTURE AND DYNAMICS OF THE DNA BINDING DOMAIN OF HMG-D FROM DROSOPHILA MELANOGASTER | Descriptor: | HMG-D | Authors: | Jones, D.N.M, Searles, M.A, Shaw, G.L, Churchill, M.E.A, Ner, S.S, Keeler, J, Travers, A.A, Neuhaus, D. | Deposit date: | 1994-05-12 | Release date: | 1994-07-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster. Structure, 2, 1994
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5MIH
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![BU of 5mih by Molmil](/molmil-images/mine/5mih) | Crystal structure of the lectin LecA from Pseudomonas aeruginosa in complex with a phenyl-epoxy-galactopyranoside | Descriptor: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CALCIUM ION, PA-I galactophilic lectin, ... | Authors: | Wagner, S, Hauk, D, Hofmann, M, Joachim, I, Sommer, R, Muller, R, Imberty, A, Varrot, A, Titz, A. | Deposit date: | 2016-11-28 | Release date: | 2017-10-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. Angew. Chem. Int. Ed. Engl., 56, 2017
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3C98
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![BU of 3c98 by Molmil](/molmil-images/mine/3c98) | Revised structure of the munc18a-syntaxin1 complex | Descriptor: | Syntaxin-1A, Syntaxin-binding protein 1 | Authors: | Hattendorf, D.A, Misura, K.M, Burkhardt, P, Scheller, R.H, Fasshauer, D, Weis, W.I. | Deposit date: | 2008-02-15 | Release date: | 2008-03-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide Embo J., 27, 2008
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1HF9
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![BU of 1hf9 by Molmil](/molmil-images/mine/1hf9) | C-Terminal Coiled-Coil Domain from Bovine IF1 | Descriptor: | ATPASE INHIBITOR (MITOCHONDRIAL) | Authors: | Gordon-Smith, D.J, Carbajo, R.J, Yang, J.-C, Videler, H, Runswick, M.J, Walker, J.E, Neuhaus, D. | Deposit date: | 2000-11-30 | Release date: | 2001-05-31 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase. J. Mol. Biol., 308, 2001
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2XCZ
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![BU of 2xcz by Molmil](/molmil-images/mine/2xcz) | Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus | Descriptor: | DI(HYDROXYETHYL)ETHER, POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN | Authors: | Wasiel, A.A, Rozeboom, H.J, Hauke, D, Baas, B.J, Zandvoort, E, Quax, W.J, Thunnissen, A.M.W.H, Poelarends, G.J. | Deposit date: | 2010-04-27 | Release date: | 2010-09-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus Marinus. Biochemistry, 49, 2010
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2XHE
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![BU of 2xhe by Molmil](/molmil-images/mine/2xhe) | Crystal structure of the Unc18-syntaxin 1 complex from Monosiga brevicollis | Descriptor: | SYNTAXIN1, UNC18 | Authors: | Burkhardt, P, Stegmann, C.M, Wahl, M.C, Fasshauer, D. | Deposit date: | 2010-06-14 | Release date: | 2011-06-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Primordial Neurosecretory Apparatus Identified in the Choanoflagellate Monosiga Brevicollis. Proc.Natl.Acad.Sci.USA, 108, 2011
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1GO5
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![BU of 1go5 by Molmil](/molmil-images/mine/1go5) | |