1CDR

STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59

Summary for 1CDR

Entry DOI	10.2210/pdb1cdr/pdb
Descriptor	CD59, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	complement regulatory protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	9540.65
Authors	Fletcher, C.M.,Harrison, R.A.,Lachmann, P.J.,Neuhaus, D. (deposition date: 1994-06-01, release date: 1994-09-30, Last modification date: 2024-11-06)
Primary citation	Fletcher, C.M.,Harrison, R.A.,Lachmann, P.J.,Neuhaus, D. Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure, 2:185-199, 1994 Cited by PubMed Abstract: CD59 is a cell-surface glycoprotein that protects host cells from complement-mediated lysis by binding to and preventing the normal functioning of the complement proteins C8 and/or C9 which form part of a membrane penetrating assembly called the membrane attack complex. CD59 has no structural similarity to other complement proteins, but is an example of a plasma protein domain type found also in murine Ly-6 proteins and the urokinase-type plasminogen activator receptor. PubMed: 7520819 DOI: 10.1016/S0969-2126(00)00020-4 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation