6Z3X
| Crystal structure of the designed antibody DesAb-anti-HSA-P1 | Descriptor: | CACODYLATE ION, DesAb-anti-HSA-P1, IMIDAZOLE, ... | Authors: | Costanzi, E, Sormanni, P, Ricagno, S. | Deposit date: | 2020-05-22 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Fragment-based computational design of antibodies targeting structured epitopes. Sci Adv, 8, 2022
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4UWN
| Lysozyme soaked with a ruthenium based CORM with a methione oxide ligand (complex 6b) | Descriptor: | CARBON MONOXIDE, CHLORIDE ION, GLYCEROL, ... | Authors: | Santos, M.F.A, Mukhopadhyay, A, Romao, M.J, Romao, C.C, Santos-Silva, T. | Deposit date: | 2014-08-13 | Release date: | 2014-12-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | A Contribution to the Rational Design of Ru(Co)3Cl2L Complexes for in Vivo Delivery of Co. Dalton Trans, 44, 2015
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7T38
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7T37
| Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2, cannabidiol | Authors: | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | Deposit date: | 2021-12-07 | Release date: | 2022-05-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
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6TNP
| Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide | Descriptor: | (2~{S})-~{N}-[2-[[(2~{S})-1-[[(2~{S},3~{R})-3-[(2~{S},3~{R},4~{R},5~{R},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-1-[[(2~{S})-1-[(2~{S})-2-aminocarbonylpyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]-1-[(2~{S})-2-azanylpropanoyl]pyrrolidine-2-carboxamide, Heavy chain of our ScFv-5E5, Light chain of our ScFv-5E5 | Authors: | Macias-Leon, J, Corzana, F, Hurtado-Guerrero, R. | Deposit date: | 2019-12-09 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody. Chem.Commun.(Camb.), 56, 2020
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7O4W
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7PQP
| tau-microtubule structural ensemble based on CryoEM data | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Isoform Tau-F of Microtubule-associated protein tau, ... | Authors: | Brotzakis, Z.F, Vendruscolo, M. | Deposit date: | 2021-09-18 | Release date: | 2021-12-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms. Acs Cent.Sci., 7, 2021
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7PQC
| tau-microtubule structural ensemble based on CryoEM data | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Isoform Tau-F of Microtubule-associated protein tau, ... | Authors: | Brotzakis, Z.F, Vendruscolo, M. | Deposit date: | 2021-09-16 | Release date: | 2021-12-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms. Acs Cent.Sci., 7, 2021
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6DG5
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | Authors: | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | Deposit date: | 2018-05-16 | Release date: | 2019-01-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.516 Å) | Cite: | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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6DG6
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | Descriptor: | Neoleukin-2/15 | Authors: | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | Deposit date: | 2018-05-16 | Release date: | 2019-01-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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4UWV
| Lysozyme soaked with a ruthenium based CORM with a pyridine ligand (complex 8) | Descriptor: | CARBON MONOXIDE, CHLORIDE ION, LYSOZYME C, ... | Authors: | Santos, M.F.A, Mukhopadhyay, A, Romao, M.J, Romao, C.C, Santos-Silva, T. | Deposit date: | 2014-08-14 | Release date: | 2014-12-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | A Contribution to the Rational Design of Ru(Co)3Cl2L Complexes for in Vivo Delivery of Co. Dalton Trans, 44, 2015
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6WKN
| PL-bound rat TRPV2 in nanodiscs | Descriptor: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | Authors: | Pumroy, R.P, Moiseenkova-Bell, V.Y. | Deposit date: | 2020-04-16 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Acs Cent.Sci., 7, 2021
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6Y54
| Crystal structure of a Neisseria meningitidis serogroup A capsular oligosaccharide bound to a functional Fab | Descriptor: | 1,2-ETHANEDIOL, Fab A1.1 H chain, Fab A1.1 L chain, ... | Authors: | Dello Iacono, L, Henriques, P, Adamo, R. | Deposit date: | 2020-02-24 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide. Proc.Natl.Acad.Sci.USA, 117, 2020
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7N0M
| Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | Authors: | Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. | Deposit date: | 2021-05-25 | Release date: | 2022-05-04 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
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7N0N
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