7O4W
Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge
Summary for 7O4W
Entry DOI | 10.2210/pdb7o4w/pdb |
Descriptor | Diphtheria toxin, 1-hydroxypropan-2-one, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | diphtheria toxin, mutant, disulphide bridge, modified disulphide bridge, acetone., toxin |
Biological source | Corynebacterium diphtheriae |
Total number of polymer chains | 1 |
Total formula weight | 59103.09 |
Authors | Veggi, D.,Dello Iacono, L. (deposition date: 2021-04-07, release date: 2022-04-06, Last modification date: 2024-01-31) |
Primary citation | Carboni, F.,Kitowski, A.,Sorieul, C.,Veggi, D.,Marques, M.C.,Oldrini, D.,Balducci, E.,Brogioni, B.,Del Bino, L.,Corrado, A.,Angiolini, F.,Dello Iacono, L.,Margarit, I.,Romano, M.R.,Bernardes, G.J.L.,Adamo, R. Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates. Chem Sci, 13:2440-2449, 2022 Cited by PubMed: 35310500DOI: 10.1039/d1sc01928g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03002061079 Å) |
Structure validation
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