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8DN3
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BU of 8dn3 by Molmil
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
Authors:Liu, X, Wang, W.
Deposit date:2022-07-10
Release date:2023-10-11
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Asymmetric gating of a human hetero-pentameric glycine receptor.
Nat Commun, 14, 2023
4B5S
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BU of 4b5s by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase, HpaI, in complex with pyruvate
Descriptor: 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, COBALT (II) ION, D-Glyceraldehyde, ...
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
7KED
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BU of 7ked by Molmil
RNA polymerase II elongation complex with unnatural base dTPT3
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Oh, J, Wang, W, Wang, D.
Deposit date:2020-10-10
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.
Nat.Chem.Biol., 17, 2021
4B5T
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BU of 4b5t by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase, HpaI, in complex with ketobutyrate
Descriptor: 2-KETOBUTYRIC ACID, 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, COBALT (II) ION, ...
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.923 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
4B5V
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BU of 4b5v by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase, HpaI, in complex with 4-hydroxyl-2-ketoheptane-1,7-dioate
Descriptor: (4R)-4-oxidanyl-2-oxidanylidene-heptanedioic acid, 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, GLYCEROL, ...
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.041 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
4B5U
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BU of 4b5u by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase, HpaI, in complex with pyruvate and succinic semialdehyde
Descriptor: 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, 4-oxobutanoic acid, COBALT (II) ION, ...
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.913 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
4B5W
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BU of 4b5w by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase R70A mutant, HpaI, in complex with pyruvate
Descriptor: 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, CALCIUM ION, COBALT (II) ION, ...
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
4B5X
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BU of 4b5x by Molmil
Crystal structures of divalent metal dependent pyruvate aldolase (HpaI), mutant D42A
Descriptor: 4-HYDROXY-2-OXO-HEPTANE-1,7-DIOATE ALDOLASE, GLYCEROL, PHOSPHATE ION
Authors:Coincon, M, Wang, W, Seah, S.Y.K, Sygusch, J.
Deposit date:2012-08-07
Release date:2012-08-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Reaction Intermediates in Pyruvate Class II Aldolase: Substrate Cleavage, Enolate Stabilization and Substrate Specificity
J.Biol.Chem., 287, 2012
5AD3
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BU of 5ad3 by Molmil
Bivalent binding to BET bromodomains
Descriptor: 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine, BROMODOMAIN-CONTAINING PROTEIN 4
Authors:Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
1N9A
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BU of 1n9a by Molmil
Farnesyltransferase complex with tetrahydropyridine inhibitors
Descriptor: 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ...
Authors:Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorg.Med.Chem.Lett., 13, 2003
1R55
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BU of 1r55 by Molmil
Crystal structure of the catalytic domain of human ADAM 33
Descriptor: (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ADAM 33, CALCIUM ION, ...
Authors:Orth, P, Reichert, P, Wang, W, Prosise, W.W, Yarosh-Tomaine, T, Hammond, G, Xiao, L, Mirza, U.A, Zou, J, Strickland, C, Taremi, S.S, Le, H.V, Madison, V.
Deposit date:2003-10-09
Release date:2004-10-12
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structre of the catalytic domain of human ADAM33
J.Mol.Biol., 335, 2004
5BKF
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BU of 5bkf by Molmil
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, Glycine bound, desensitized state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alpha-2, ...
Authors:Yu, H, Wang, W.
Deposit date:2021-03-19
Release date:2021-09-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Characterization of the subunit composition and structure of adult human glycine receptors
Neuron, 109, 2021
5BKG
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BU of 5bkg by Molmil
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, glycine bound, (semi)open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alpha-2, ...
Authors:Yu, H, Wang, W.
Deposit date:2021-03-19
Release date:2021-09-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Characterization of the subunit composition and structure of adult human glycine receptors
Neuron, 109, 2021
5CIO
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BU of 5cio by Molmil
Crystal structure of PqqF
Descriptor: ZINC ION, pyrroloquinoline quinone biosynthesis protein PqqF
Authors:Wei, Q, Xu, D, Ran, T, Wang, W.
Deposit date:2015-07-13
Release date:2016-06-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure and Function of PqqF Protein in the Pyrroloquinoline Quinone Biosynthetic Pathway
J.Biol.Chem., 291, 2016
1N95
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BU of 1n95 by Molmil
Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives
Descriptor: 1-[2-(4-CYANO-BENZYLAMINO)-3-(3-METHYL-3H-IMIDAZOL-4-YL)-PROPIONYL]-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ...
Authors:Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorg.Med.Chem.Lett., 13, 2003
1R54
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BU of 1r54 by Molmil
Crystal structure of the catalytic domain of human ADAM33
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 33, CALCIUM ION, ...
Authors:Orth, P, Reicher, P, Wang, W, Prosise, W.W, Yarosh-Tomaine, T, Hammond, G, Xiao, L, Mirza, U.A, Zou, J, Strickland, C, Taremi, S.S.
Deposit date:2003-10-09
Release date:2004-10-12
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structre of the catalytic domain of human ADAM33
J.Mol.Biol., 335, 2004
5CZW
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BU of 5czw by Molmil
Crystal structure of myroilysin
Descriptor: Myroilysin, ZINC ION
Authors:Zhou, J, Ran, T, Xu, D, Wang, W.
Deposit date:2015-08-01
Release date:2016-08-03
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism
J. Biol. Chem., 292, 2017
8K5Q
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BU of 8k5q by Molmil
Crystal structure of YajQ STM0435 with c-di-GMP
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), YajQ
Authors:Dai, Y, Zhang, M, Wang, W, Li, B.
Deposit date:2023-07-23
Release date:2024-04-17
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A c-di-GMP binding effector STM0435 modulates flagellar motility and pathogenicity in Salmonella
Virulence, 15, 2024
8K4I
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BU of 8k4i by Molmil
Crystal structure of YajQ STM0435
Descriptor: YajQ
Authors:Dai, Y, Zhang, M, Wang, W, Li, B.
Deposit date:2023-07-19
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:A c-di-GMP binding effector STM0435 modulates flagellar motility and pathogenicity in Salmonella
Virulence, 15, 2024
5AD2
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BU of 5ad2 by Molmil
Bivalent binding to BET bromodomains
Descriptor: (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone, BROMODOMAIN-CONTAINING PROTEIN 4
Authors:Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
1N94
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BU of 1n94 by Molmil
Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates
Descriptor: 2-{(5-{[BUTYL-(2-CYCLOHEXYL-ETHYL)-AMINO]-METHYL}-2'-METHYL-BIPHENYL-2-CARBONYL)-AMINO]-4-METHYLSULFANYL-BUTYRIC ACID, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ...
Authors:Gwaltney II, S.L, O'Connor, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorg.Med.Chem.Lett., 13, 2003
4JHR
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BU of 4jhr by Molmil
An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs
Descriptor: G-protein-signaling modulator 2
Authors:Pan, Z, Zhu, J, Shang, Y, Wei, Z, Jia, M, Xia, C, Wen, W, Wang, W, Zhang, M.
Deposit date:2013-03-05
Release date:2013-06-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs
Structure, 21, 2013
1T6Z
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BU of 1t6z by Molmil
Crystal structure of riboflavin bound TM379
Descriptor: RIBOFLAVIN, riboflavin kinase/FMN adenylyltransferase
Authors:Shin, D.H, Wang, W, Kim, R, Yokota, H, Kim, S.-H, Berkeley Structural Genomics Center (BSGC)
Deposit date:2004-05-07
Release date:2004-08-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of ADP bound FAD synthetase
To be Published
3C4E
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BU of 3c4e by Molmil
Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole
Descriptor: IMIDAZOLE, N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine, Proto-oncogene serine/threonine-protein kinase Pim-1
Authors:Zhang, K.Y.J, Wang, W.
Deposit date:2008-01-29
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
5D7W
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BU of 5d7w by Molmil
Crystal structure of serralysin
Descriptor: CALCIUM ION, GLYCEROL, Serralysin, ...
Authors:Wu, D, Ran, T, Xu, D.Q, Wang, W.
Deposit date:2015-08-14
Release date:2016-01-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structure of a thermostable serralysin from Serratia sp. FS14 at 1.1 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016

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