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6XCQ
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Erythromycin esterase EreC, mutant H289N in its closed conformation
分子名称: EreC, S-1,2-PROPANEDIOL
著者Zielinski, M, Park, J, Berghuis, A.M.
登録日2020-06-09
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional insights into esterase-mediated macrolide resistance.
Nat Commun, 12, 2021
6XCS
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BU of 6xcs by Molmil
Erythromycin esterase mutant EreC H289N in its open conformation
分子名称: EreC
著者Zielinski, M, Berghuis, A.M.
登録日2020-06-09
公開日2021-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and functional insights into esterase-mediated macrolide resistance.
Nat Commun, 12, 2021
7MQK
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AAC(3)-IIIa in complex with CoA and sisomicin
分子名称: (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, Aminoglycoside N(3)-acetyltransferase III, COENZYME A, ...
著者Zielinski, M, Berghuis, A.M.
登録日2021-05-05
公開日2022-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
Plos One, 17, 2022
7MQL
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AAC(3)-IIIa in complex with CoA and neomycin
分子名称: Aminoglycoside N(3)-acetyltransferase III, COENZYME A, FORMIC ACID, ...
著者Zielinski, M, Berghuis, A.M.
登録日2021-05-05
公開日2022-07-06
最終更新日2022-08-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
Plos One, 17, 2022
7MQM
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AAC(3)-IIIa in complex with CoA and gentamicin
分子名称: Aminoglycoside N(3)-acetyltransferase III, COENZYME A, GLYCEROL, ...
著者Zielinski, M, Berghuis, A.M.
登録日2021-05-05
公開日2022-07-06
最終更新日2022-08-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
Plos One, 17, 2022
8OL2
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Murine type II Abeta fibril from APP23 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OL3
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BU of 8ol3 by Molmil
Murine type III Abeta fibril from APP/PS1 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OLQ
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DI3 Abeta fibril from tg-SwDI mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OL7
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BU of 8ol7 by Molmil
MurineArc type I Abeta fibril from tg-APPArcSwe mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OL6
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BU of 8ol6 by Molmil
Murine type II Abeta fibril from tgAPPSwe mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OLO
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BU of 8olo by Molmil
Murine type III Abeta fibril from ARTE10 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OLG
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BU of 8olg by Molmil
DI2 Abeta fibril from tg-SwDI mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OLN
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BU of 8oln by Molmil
DI1 Abeta fibril from tg-SwDI mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OL5
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BU of 8ol5 by Molmil
Murine type II Abeta fibril from ARTE10 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
5JA0
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BU of 5ja0 by Molmil
Crystal structure of human FPPS with allosterically bound FPP
分子名称: FARNESYL DIPHOSPHATE, Farnesyl pyrophosphate synthase, PHOSPHATE ION
著者Park, J, Zielinski, M, Tsantrizos, Y.S, Berghuis, A.M.
登録日2016-04-11
公開日2017-01-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.
Nat Commun, 8, 2017
4QXS
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BU of 4qxs by Molmil
Crystal structure of human FPPS in complex with WC01088
分子名称: (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, GLYCEROL, ...
著者Park, J, Zielinski, M, Weiling, C, Tsantrizos, Y.S, Berghuis, A.M.
登録日2014-07-21
公開日2015-02-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg.Med.Chem.Lett., 25, 2015
7UQ2
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Vs.4 from T4 phage in complex with cGAMP
分子名称: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, Vs.4
著者Jenson, J.M, Chen, Z.J.
登録日2022-04-18
公開日2023-02-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence.
Nature, 616, 2023
7PFP
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Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B.
登録日2021-08-11
公開日2022-03-16
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7P6S
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Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2, pentane-1,5-diol
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7P6T
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Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethyl-2-(hydroxymethyl)propane-1,3-diol, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7P6R
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Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2
著者Stsiapanava, A, Tunyasuvunakool, K, Jumper, J, de Sanctis, D, Jovine, L.
登録日2021-07-17
公開日2022-03-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7Q3N
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Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Type 1 fimbiral adhesin FimH, ...
著者Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B.
登録日2021-10-28
公開日2022-03-16
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (7.4 Å)
主引用文献Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022

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