7P6T

Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)

Summary for 7P6T

Entry DOI	10.2210/pdb7p6t/pdb
Related	7P6R 7P6S
Descriptor	Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethyl-2-(hydroxymethyl)propane-1,3-diol, ... (4 entities in total)
Functional Keywords	extracellular matrix, glycoprotein, n-glycan, structural protein, decoy module, d10c domain, d8c sequence, pancreas, intestine, mucosal immunity, fimh, alphafold, antimicrobial protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	19245.35
Authors	Stsiapanava, A.,Tunyasuvunakool, K.,Jumper, J.,de Sanctis, D.,Jovine, L. (deposition date: 2021-07-17, release date: 2022-03-16, Last modification date: 2022-03-30)
Primary citation	Stsiapanava, A.,Xu, C.,Nishio, S.,Han, L.,Yamakawa, N.,Carroni, M.,Tunyasuvunakool, K.,Jumper, J.,de Sanctis, D.,Wu, B.,Jovine, L. Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Nat.Struct.Mol.Biol., 29:190-193, 2022 Cited by PubMed: 35273390 DOI: 10.1038/s41594-022-00729-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation