4QXS
Crystal structure of human FPPS in complex with WC01088
Summary for 4QXS
Entry DOI | 10.2210/pdb4qxs/pdb |
Descriptor | Farnesyl pyrophosphate synthase, PHOSPHATE ION, (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43878.41 |
Authors | Park, J.,Zielinski, M.,Weiling, C.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2014-07-21, release date: 2015-02-25, Last modification date: 2023-09-20) |
Primary citation | Gritzalis, D.,Park, J.,Chiu, W.,Cho, H.,Lin, Y.S.,De Schutter, J.W.,Lacbay, C.M.,Zielinski, M.,Berghuis, A.M.,Tsantrizos, Y.S. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorg.Med.Chem.Lett., 25:1117-1123, 2015 Cited by PubMed: 25630225DOI: 10.1016/j.bmcl.2014.12.089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report