7P6R

Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)

Summary for 7P6R

• Entry DOI: 10.2210/pdb7p6r/pdb
• Related: 7P6S 7P6T
• Descriptor: Isoform Alpha of Pancreatic secretory granule membrane major glycoprotein GP2, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: extracellular matrix, glycoprotein, n-glycan, structural protein, decoy module, d10c domain, d8c sequence, pancreas, intestine, mucosal immunity, fimh, alphafold, antimicrobial protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37486.36

Authors

Stsiapanava, A.,Tunyasuvunakool, K.,Jumper, J.,de Sanctis, D.,Jovine, L. (deposition date: 2021-07-17, release date: 2022-03-16, Last modification date: 2022-03-30)

• Primary citation: Stsiapanava, A.,Xu, C.,Nishio, S.,Han, L.,Yamakawa, N.,Carroni, M.,Tunyasuvunakool, K.,Jumper, J.,de Sanctis, D.,Wu, B.,Jovine, L.; Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.; Nat.Struct.Mol.Biol., 29:190-193, 2022; PubMed: 35273390; DOI: 10.1038/s41594-022-00729-3

Experimental method

X-RAY DIFFRACTION (1.9 Å)