6LAR
| Structure of ESX-3 complex | 分子名称: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | 著者 | Wang, S.H, Zhou, K.X, Li, J, Rao, Z.H. | 登録日 | 2019-11-13 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | cryo-em structure of esx-3 To Be Published
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1VKT
| HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES | 分子名称: | INSULIN | 著者 | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1996-10-14 | 公開日 | 1997-04-01 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J.Mol.Biol., 264, 1996
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3JSD
| Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | 登録日 | 2009-09-10 | 公開日 | 2010-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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1SJT
| MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES | 分子名称: | PROINSULIN | 著者 | Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1997-10-09 | 公開日 | 1998-03-18 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures. J.Mol.Biol., 277, 1998
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1SJU
| MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES | 分子名称: | PROINSULIN | 著者 | Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 1997-10-09 | 公開日 | 1998-03-18 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures. J.Mol.Biol., 277, 1998
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3ROV
| Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | 登録日 | 2011-04-26 | 公開日 | 2012-05-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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6JOH
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2JMN
| NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2006-11-21 | 公開日 | 2006-12-05 | 最終更新日 | 2023-12-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J.Mol.Biol., 264, 1996
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3OSF
| The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-2f-13 DNA | 分子名称: | 5'-D(*CP*AP*AP*GP*AP*CP*GP*AP*TP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*AP*TP*CP*GP*TP*CP*TP*TP*G)-3', ISOPROPYL ALCOHOL, ... | 著者 | Jiang, I, Tsai, C.K, Chen, S.C, Wang, S.H, Amiraslanov, I, Chang, C.F, Wu, W.J, Tai, J.H, Liaw, Y.C, Huang, T.H. | 登録日 | 2010-09-09 | 公開日 | 2011-08-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.032 Å) | 主引用文献 | Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis. Nucleic Acids Res., 39, 2011
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3OSG
| The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-1-12 DNA | 分子名称: | 5'-D(*AP*AP*AP*TP*AP*TP*CP*GP*TP*TP*AP*T)-3', 5'-D(*AP*TP*AP*AP*CP*GP*AP*TP*AP*TP*TP*T)-3', MYB21 | 著者 | Jiang, I, Tsai, C.K, Chen, S.C, Wang, S.H, Amiraslanov, I, Chang, C.F, Wu, W.J, Tai, J.H, Liaw, Y.C, Huang, T.H. | 登録日 | 2010-09-09 | 公開日 | 2011-08-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis. Nucleic Acids Res., 39, 2011
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6J19
| ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ESAT-6-like protein EsxB, ESX-1 secretion system protein EccCb1, ... | 著者 | Wang, S.H, Li, J, Rao, Z.H. | 登録日 | 2018-12-28 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | 主引用文献 | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6J18
| ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ESX-5 secretion system protein EccC5, MAGNESIUM ION | 著者 | Wang, S.H, Li, J, Rao, Z.H. | 登録日 | 2018-12-28 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6JD5
| ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein, MAGNESIUM ION | 著者 | Wang, S.H, Li, J, Rao, Z.H. | 登録日 | 2019-01-31 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6J17
| ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ESX-3 secretion system protein EccC3, MAGNESIUM ION | 著者 | Wang, S.H, Li, J, Rao, Z.H. | 登録日 | 2018-12-28 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.975 Å) | 主引用文献 | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6JD4
| ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ESX-1 secretion system protein EccCb1, MAGNESIUM ION | 著者 | Wang, S.H, Li, J, Rao, Z.H. | 登録日 | 2019-01-31 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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4NPN
| Crystal structure of human tetra-SUMO-2 | 分子名称: | Small ubiquitin-related modifier 2 | 著者 | Kung, C.C.-H, Naik, M.T, Chen, C.L, Ma, C, Huang, T.H. | 登録日 | 2013-11-22 | 公開日 | 2014-10-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.633 Å) | 主引用文献 | Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. Biochem.J., 462, 2014
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4XGY
| GFP based antibody (fluorobody) | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Green fluorescent protein, mAb LCDR3 | 著者 | Shi, N, Chen, Y.G, Wang, S.H. | 登録日 | 2015-01-03 | 公開日 | 2015-07-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.494 Å) | 主引用文献 | The structure of a GFP-based antibody (fluorobody) to TLH, a toxin from Vibrio parahaemolyticus. Acta Crystallogr.,Sect.F, 71, 2015
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5XGF
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8HQN
| Activation mechanism of GPR132 by 9(S)-HODE | 分子名称: | (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HVI
| Activation mechanism of GPR132 by compound NOX-6-7 | 分子名称: | 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQM
| Activation mechanism of GPR132 by NPGLY | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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8HQE
| Cryo-EM structure of the apo-GPR132-Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
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1KMF
| NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | 分子名称: | Insulin | 著者 | Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2001-12-14 | 公開日 | 2002-01-09 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue. J.Mol.Biol., 316, 2002
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1JCA
| Non-standard Design of Unstable Insulin Analogues with Enhanced Activity | 分子名称: | ZINC ION, insulin a, insulin b | 著者 | Weiss, M.A, Wan, Z, Zhao, M, Chu, Y.-C, Nakagawa, S.H, Burke, G.T, Jia, W, Hellmich, R, Katsoyannis, P.G. | 登録日 | 2001-06-08 | 公開日 | 2001-06-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. J.Mol.Biol., 315, 2002
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1J73
| Crystal structure of an unstable insulin analog with native activity. | 分子名称: | ZINC ION, insulin a, insulin b | 著者 | Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A. | 登録日 | 2001-05-15 | 公開日 | 2001-05-30 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. J.Mol.Biol., 315, 2002
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