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3C8Z
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BU of 3c8z by Molmil
The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Cysteinyl-tRNA synthetase, ...
著者Tremblay, L.W, Fan, F, Vetting, M.W, Blanchard, J.S.
登録日2008-02-14
公開日2008-12-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.
Biochemistry, 47, 2008
3CG5
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BU of 3cg5 by Molmil
Crystal Structure of the Covalent Adduct Formed between TB B-lactamase and Clavulanate
分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S.
登録日2008-03-04
公開日2008-05-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.
Biochemistry, 47, 2008
2C4N
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BU of 2c4n by Molmil
NagD from E.coli K-12 strain
分子名称: MAGNESIUM ION, PHOSPHATE ION, PROTEIN NAGD
著者Tremblay, L.W, Dunaway-Mariano, D, Allen, K.
登録日2005-10-20
公開日2006-01-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and Activity Analyses of Escherichia Coli K-12 Nagd Provide Insight Into the Evolution of Biochemical Function in the Haloalkanoic Acid Dehalogenase Superfamily
Biochemistry, 45, 2006
3IQA
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BU of 3iqa by Molmil
Crystal Structure of BlaC covalently bound with Doripenem
分子名称: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2009-08-19
公開日2010-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49, 2010
3HT5
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BU of 3ht5 by Molmil
Crystal Structure of IlvE a Branched Chain Amino Acid Transaminase from Mycobacterium tuberculosis
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, branched-chain-amino-acid aminotransferase
著者Tremblay, L.W, Blanchard, J.S.
登録日2009-06-11
公開日2009-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.F, 65, 2009
1Z4O
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BU of 1z4o by Molmil
Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate
分子名称: 1-O-phosphono-alpha-D-galactopyranose, Beta-phosphoglucomutase, MAGNESIUM ION
著者Tremblay, L.W, Zhang, G, Dai, J, Dunaway-Mariano, D, Allen, K.N.
登録日2005-03-16
公開日2005-04-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Chemical Confirmation of a Pentavalent Phosphorane in Complex with beta-Phosphoglucomutase
J.Am.Chem.Soc., 127, 2005
1Z4N
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BU of 1z4n by Molmil
Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride
分子名称: 1-O-phosphono-alpha-D-galactopyranose, Beta-phosphoglucomutase, MAGNESIUM ION
著者Tremblay, L.W, Zhang, G, Dai, J, Dunaway-Mariano, D, Allen, K.N.
登録日2005-03-16
公開日2005-04-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Chemical Confirmation of a Pentavalent Phosphorane in Complex with beta-Phosphoglucomutase
J.Am.Chem.Soc., 127, 2005
3M6B
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BU of 3m6b by Molmil
Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase
分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Fan, F, Blanchard, J.S.
登録日2010-03-15
公開日2010-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49, 2010
3NC8
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BU of 3nc8 by Molmil
Crystal Structure of BlaC-E166A covalently bound with Mecillinam
分子名称: 2-[(1R)-1-{[(E)-azepan-1-ylmethylidene]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-04
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3M6H
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BU of 3m6h by Molmil
Crystal Structure of Post-isomerized Ertapenem Covalent Adduct with TB B-lactamase
分子名称: (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W.
登録日2010-03-15
公開日2010-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49, 2010
3NY4
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BU of 3ny4 by Molmil
Crystal Structure of BlaC-K73A bound with Cefamandole
分子名称: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-07-14
公開日2010-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010
3N8R
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BU of 3n8r by Molmil
Crystal Structure of BlaC-E166A covalently bound with Carbenicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献BlaC-E166A bound with beta-lactams from all classes
To be Published
3NDG
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BU of 3ndg by Molmil
Crystal Structure of BlaC-E166A covalently bound with Methicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2,6-dimethoxyphenyl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-07
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3N8L
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BU of 3n8l by Molmil
Crystal Structure of BlaC-E166A covalently bound with Ampicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structures of BlaC-E166A covalently bound to beta-lactams from all classes.
To be Published
3NDE
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BU of 3nde by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cephalotin
分子名称: (2R)-5-[(acetyloxy)methyl]-2-{(1R)-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-07
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NCK
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BU of 3nck by Molmil
Crystal Structure of BlaC-E166A covalently bound with Nafcillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-04
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NBL
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BU of 3nbl by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cefuroxime
分子名称: (2R)-5-[(carbamoyloxy)methyl]-2-[(1R)-1-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-06-03
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3N7W
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BU of 3n7w by Molmil
Crystal Structure of BlaC-E166A covalently bound with Amoxicillin
分子名称: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-27
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献BlaC-E166A Bound with btea-lactams of all classes
To be Published
3N8S
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BU of 3n8s by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cefamandole
分子名称: (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-28
公開日2010-11-24
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010
3N6I
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BU of 3n6i by Molmil
Crystal Structure of BlaC-E166A covalently bound with 6-aminopenicillian
分子名称: (2R,4S)-2-[(1R)-1-amino-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Blanchard, J.S.
登録日2010-05-25
公開日2011-12-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Structure Activity Relationship of BlaC with all classes of beta-lactams
To be Published
3DWZ
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BU of 3dwz by Molmil
Meropenem Covalent Adduct with TB Beta-lactamase
分子名称: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION
著者Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S.
登録日2008-07-23
公開日2009-03-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
Science, 323, 2009
1ZOL
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BU of 1zol by Molmil
native beta-PGM
分子名称: MAGNESIUM ION, beta-phosphoglucomutase
著者Zhang, G, Tremblay, L.W, Dai, J, Wang, L, Dunaway-Mariano, D, Allen, K.N.
登録日2005-05-13
公開日2005-08-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis
Biochemistry, 44, 2005
4JLF
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BU of 4jlf by Molmil
Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase
分子名称: Beta-lactamase, PHOSPHATE ION
著者Hazra, S, Kurz, S, Blanchard, J, Bonomo, R.
登録日2013-03-12
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Antimicrob.Agents Chemother., 57, 2013

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件を2024-06-12に公開中

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