3DWZ
Meropenem Covalent Adduct with TB Beta-lactamase
Summary for 3DWZ
Entry DOI | 10.2210/pdb3dwz/pdb |
Related | 3cg5 |
Descriptor | Beta-lactamase, PHOSPHATE ION, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total) |
Functional Keywords | alpha-beta folded protein, protein-covalent adduct, antibiotic resistance, hydrolase, lipoprotein, membrane, palmitate, meropenem (open form), hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 28848.14 |
Authors | Tremblay, L.W.,Hugonnet, J.E.,Blanchard, J.S. (deposition date: 2008-07-23, release date: 2009-03-10, Last modification date: 2023-08-30) |
Primary citation | Hugonnet, J.E.,Tremblay, L.W.,Boshoff, H.I.,Barry, C.E.,Blanchard, J.S. Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323:1215-1218, 2009 Cited by PubMed: 19251630DOI: 10.1126/science.1167498 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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