3DWZ

Meropenem Covalent Adduct with TB Beta-lactamase

Summary for 3DWZ

Entry DOI	10.2210/pdb3dwz/pdb
Related	3cg5
Descriptor	Beta-lactamase, PHOSPHATE ION, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total)
Functional Keywords	alpha-beta folded protein, protein-covalent adduct, antibiotic resistance, hydrolase, lipoprotein, membrane, palmitate, meropenem (open form), hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	28848.14
Authors	Tremblay, L.W.,Hugonnet, J.E.,Blanchard, J.S. (deposition date: 2008-07-23, release date: 2009-03-10, Last modification date: 2023-08-30)
Primary citation	Hugonnet, J.E.,Tremblay, L.W.,Boshoff, H.I.,Barry, C.E.,Blanchard, J.S. Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323:1215-1218, 2009 Cited by PubMed: 19251630 DOI: 10.1126/science.1167498 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation