8I3V
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![BU of 8i3v by Molmil](/molmil-images/mine/8i3v) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | 分子名称: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2023-01-18 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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6M11
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![BU of 6m11 by Molmil](/molmil-images/mine/6m11) | Crystal structure of Rnase L in complex with Sunitinib | 分子名称: | 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, PHOSPHATE ION, ... | 著者 | Tang, J, Huang, H. | 登録日 | 2020-02-24 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J., 477, 2020
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6M12
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![BU of 6m12 by Molmil](/molmil-images/mine/6m12) | Crystal Structure of Rnase L in complex with SU11652 | 分子名称: | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, PHOSPHATE ION, Ribonuclease L, ... | 著者 | Tang, J, Huang, H. | 登録日 | 2020-02-24 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J., 477, 2020
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2W2G
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![BU of 2w2g by Molmil](/molmil-images/mine/2w2g) | Human SARS coronavirus unique domain | 分子名称: | NON-STRUCTURAL PROTEIN 3, SULFATE ION | 著者 | Tan, J, Vonrhein, C, Smart, O.S, Bricogne, G, Bollati, M, Kusov, Y, Hansen, G, Mesters, J.R, Schmidt, C.L, Hilgenfeld, R. | 登録日 | 2008-10-30 | 公開日 | 2009-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | The Sars-Unique Domain (Sud) of Sars Coronavirus Contains Two Macrodomains that Bind G-Quadruplexes. Plos Pathog., 5, 2009
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2WCT
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![BU of 2wct by Molmil](/molmil-images/mine/2wct) | human SARS coronavirus unique domain (triclinic form) | 分子名称: | NON-STRUCTURAL PROTEIN 3 | 著者 | Tan, J, Vonrhein, C, Smart, O.S, Bricogne, G, Bollati, M, Hansen, G, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2009-03-16 | 公開日 | 2009-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | The Sars-Unique Domain (Sud) of Sars Coronavirus Contains Two Macrodomains that Bind G-Quadruplexes. Plos Pathog., 5, 2009
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3VXV
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![BU of 3vxv by Molmil](/molmil-images/mine/3vxv) | Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*CP*(5CM)P*GP*GP*AP*CP*A)-3'), ... | 著者 | Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M. | 登録日 | 2012-09-21 | 公開日 | 2013-01-16 | 最終更新日 | 2013-08-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4 J.Biol.Chem., 288, 2013
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6EYW
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![BU of 6eyw by Molmil](/molmil-images/mine/6eyw) | |
8HFE
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![BU of 8hfe by Molmil](/molmil-images/mine/8hfe) | Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom | 分子名称: | CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFF
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![BU of 8hff by Molmil](/molmil-images/mine/8hff) | Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom. | 分子名称: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFL
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![BU of 8hfl by Molmil](/molmil-images/mine/8hfl) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom. | 分子名称: | Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-11 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFI
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![BU of 8hfi by Molmil](/molmil-images/mine/8hfi) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom. | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFG
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![BU of 8hfg by Molmil](/molmil-images/mine/8hfg) | Cryo-EM structure of human norepinephrine transporter NET in the presence of dopamine in an inward-open state at resolution of 3.0 angstrom. | 分子名称: | CHLORIDE ION, L-DOPAMINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HTD
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![BU of 8htd by Molmil](/molmil-images/mine/8htd) | Crystal structure of an effector from Chromobacterium violaceum in complex with ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, Ubiquitin | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTC
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![BU of 8htc by Molmil](/molmil-images/mine/8htc) | Crystal structure of a SeMet-labeled effector from Chromobacterium violaceum in complex with Ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, Ubiquitin-40S ribosomal protein S27a (Fragment) | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTE
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![BU of 8hte by Molmil](/molmil-images/mine/8hte) | Crystal structure of an effector mutant in complex with ubiquitin | 分子名称: | GLYCEROL, NAD(+)--protein-threonine ADP-ribosyltransferase, NICOTINAMIDE, ... | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTF
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![BU of 8htf by Molmil](/molmil-images/mine/8htf) | Crystal structure of an effector in complex with ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Ubiquitin-40S ribosomal protein S27a (Fragment) | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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7DSY
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![BU of 7dsy by Molmil](/molmil-images/mine/7dsy) | Crystal Structure of RNase L in complex with KM05073 | 分子名称: | 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, ... | 著者 | Tang, J, Huang, H. | 登録日 | 2021-01-03 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.651 Å) | 主引用文献 | Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65, 2022
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3ZVG
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![BU of 3zvg by Molmil](/molmil-images/mine/3zvg) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 98 | 分子名称: | 3C PROTEASE, N-(tert-butoxycarbonyl)-O-tert-butyl-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVE
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![BU of 3zve by Molmil](/molmil-images/mine/3zve) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 84 | 分子名称: | 3C PROTEASE, O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZV9
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![BU of 3zv9 by Molmil](/molmil-images/mine/3zv9) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 74 | 分子名称: | 3C PROTEASE, ETHYL (4R)-4-[(TERT-BUTOXYCARBONYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVC
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![BU of 3zvc by Molmil](/molmil-images/mine/3zvc) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 82 | 分子名称: | 3C PROTEASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVD
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![BU of 3zvd by Molmil](/molmil-images/mine/3zvd) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 83 | 分子名称: | 3C PROTEASE, ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZVB
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![BU of 3zvb by Molmil](/molmil-images/mine/3zvb) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 81 | 分子名称: | 3C PROTEASE, ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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3ZV8
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![BU of 3zv8 by Molmil](/molmil-images/mine/3zv8) | |
3ZVF
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![BU of 3zvf by Molmil](/molmil-images/mine/3zvf) | 3C protease of Enterovirus 68 complexed with Michael receptor inhibitor 85 | 分子名称: | 3C PROTEASE, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide | 著者 | Tan, J, Perbandt, M, Mesters, J.R, Hilgenfeld, R. | 登録日 | 2011-07-24 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses. J.Virol., 87, 2013
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