7DSY
Crystal Structure of RNase L in complex with KM05073
Summary for 7DSY
Entry DOI | 10.2210/pdb7dsy/pdb |
Descriptor | Ribonuclease L, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one, ... (5 entities in total) |
Functional Keywords | rnase l, inhibitor, km05073, fragment, hydrolase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 2 |
Total formula weight | 165259.41 |
Authors | |
Primary citation | Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H. Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem., 65:1445-1457, 2022 Cited by DOI: 10.1021/acs.jmedchem.1c01156PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.651 Å) |
Structure validation
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