6M11

Crystal structure of Rnase L in complex with Sunitinib

Summary for 6M11

• Entry DOI: 10.2210/pdb6m11/pdb
• Descriptor: Ribonuclease L, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, rnase l, sunitinib, hydrolase
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 2
• Total formula weight: 165558.86

Authors

Tang, J.,Huang, H. (deposition date: 2020-02-24, release date: 2020-09-02, Last modification date: 2023-11-29)

• Primary citation: Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H.; Sunitinib inhibits RNase L by destabilizing its active dimer conformation.; Biochem.J., 477:3387-3399, 2020; PubMed: 32830849; DOI: 10.1042/BCJ20200260

Experimental method

X-RAY DIFFRACTION (2.46 Å)