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6Z2C
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BU of 6z2c by Molmil
Engineered lipocalin C3A5 in complex with a transition state analog
分子名称: 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2020-05-15
公開日2021-05-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published
6Z6Z
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BU of 6z6z by Molmil
Crystal structure of an Anticalin directed towards colchicine without ligand
分子名称: CALCIUM ION, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2020-05-29
公開日2021-06-09
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural rearrangement in the ligand pocket of Colchicalin upon Colchicine binding
To be published
6ZVF
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BU of 6zvf by Molmil
Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
分子名称: Chimeric Fab M3/38 (L,H), Galectin-3
著者Skerra, A, Eichinger, A.
登録日2020-07-24
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.
Sci Rep, 11, 2021
6GR0
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BU of 6gr0 by Molmil
Petrobactin-binding engineered lipocalin in complex with gallium-petrobactin
分子名称: 4-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-[2-[4-[3-[[3,4-bis(oxidanyl)phenyl]carbonylamino]propylamino]butylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-4-oxidanylidene-butanoic acid, GALLIUM (III) ION, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
6GQZ
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BU of 6gqz by Molmil
Petrobactin-binding engineered lipocalin without ligand
分子名称: Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2018-06-08
公開日2018-08-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
6QBB
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BU of 6qbb by Molmil
Engineered streptavidin variant (ENAGY) in complex with the Strep-tag II peptide
分子名称: Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2018-12-20
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6QSY
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BU of 6qsy by Molmil
Engineered streptavidin variant (H--WY) in complex with the Strep-tag II peptide
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Strep-tag II peptide, Streptavidin, ...
著者Skerra, A, Eichinger, A.
登録日2019-02-22
公開日2020-03-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6QMU
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BU of 6qmu by Molmil
A tetrahedral boronic acid diester formed by a non-natural amino acid in the ligand pocket of an engineered lipocalin
分子名称: 3-nitrophenol, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A.
登録日2019-02-08
公開日2019-08-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin.
Chembiochem, 21, 2020
3P7F
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BU of 3p7f by Molmil
Structure of the human Langerin carbohydrate recognition domain
分子名称: C-type lectin domain family 4 member K, CALCIUM ION
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
3P7G
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BU of 3p7g by Molmil
Structure of the human Langerin carbohydrate recognition domain in complex with mannose
分子名称: C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-mannopyranose
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
3P7H
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BU of 3p7h by Molmil
Structure of the human Langerin carbohydrate recognition domain in complex with maltose
分子名称: C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Skerra, A, Schiefner, A.
登録日2010-10-12
公開日2010-11-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Mol.Immunol., 45, 2008
6QW4
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BU of 6qw4 by Molmil
Engineered streptavidin variant (ACGR) in complex with the Strep-tag II peptide
分子名称: Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2019-03-05
公開日2020-03-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6SOK
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BU of 6sok by Molmil
Engineered streptavidin variant (VTAR) in complex with the Twin-Strep-tag peptide
分子名称: AMINO GROUP, Streptavidin, Twin-Strep-tag peptide
著者Skerra, A, Eichinger, A.
登録日2019-08-29
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6SOS
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BU of 6sos by Molmil
Engineered streptavidin variant (ENAGY) in complex with the Twin-Strep-tag peptide
分子名称: Streptavidin, Twin-Strep-tag peptide
著者Skerra, A, Eichinger, A.
登録日2019-08-29
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
6TIP
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BU of 6tip by Molmil
Engineered streptavidin variant (YNAFM) in complex with the Strep-tag II peptide
分子名称: AMINO GROUP, Strep-tag II peptide, Streptavidin
著者Skerra, A, Eichinger, A.
登録日2019-11-22
公開日2020-12-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Role of Changing Loop Conformations in Streptavidin Versions Engineered for High-affinity Binding of the Strep-tag II Peptide.
J.Mol.Biol., 433, 2021
5MHH
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BU of 5mhh by Molmil
Crystal structure of engineered human lipocalin 2 carrying p-boronophenylalanine at position 36
分子名称: Neutrophil gelatinase-associated lipocalin, SULFATE ION
著者Skerra, A, Eichinger, A.
登録日2016-11-24
公開日2017-10-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain.
ACS Synth Biol, 6, 2017
5NKN
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BU of 5nkn by Molmil
Crystal structure of an Anticalin-colchicine complex
分子名称: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin
著者Skerra, A, Eichinger, A, Barkovskiy, M.
登録日2017-03-31
公開日2018-04-04
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.
Biol. Chem., 400, 2019
5NBW
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BU of 5nbw by Molmil
Crystal structure of the Fab fragment 22F12 in complex with 3-hydroxybenzo[a]pyrene
分子名称: Fab 22F12 (A,B), Fab 22F12 (L,H), benzo[a]pyren-3-ol
著者Skerra, A, Eichinger, A.
登録日2017-03-02
公開日2017-06-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Tight Molecular Recognition of Benzo[a]pyrene by a High-Affinity Antibody.
Angew. Chem. Int. Ed. Engl., 56, 2017
3BX7
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BU of 3bx7 by Molmil
Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
分子名称: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2
著者Schonfeld, D.L, Chatwell, L, Skerra, A.
登録日2008-01-11
公開日2009-01-20
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
1GPO
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BU of 1gpo by Molmil
CRYSTAL STRUCTURE OF THE RATIONALLY DESIGNED ANTIBODY M41 AS A FAB FRAGMENT
分子名称: ANTIBODY M41, SULFATE ION
著者Schiweck, W, Skerra, A.
登録日1997-03-27
公開日1998-04-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The rational construction of an antibody against cystatin: lessons from the crystal structure of an artificial Fab fragment.
J.Mol.Biol., 268, 1997
8B50
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BU of 8b50 by Molmil
Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine
分子名称: (2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid, Fab fragment K12F9-22 - heavy chain, Fab fragment K12F9-22 - light chain, ...
著者Meining, W, Eichinger, A, Skerra, A.
登録日2022-09-21
公開日2023-10-04
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Preparation and characterization of monoclonal antibodies against a non natural amino acid carrying the 7-hydroxycoumarin side chain
To be published
1RST
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BU of 1rst by Molmil
COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG PEPTIDE
分子名称: STREP-TAG PEPTIDE, STREPTAVIDIN
著者Koepke, J, Schmidt, T, Skerra, A.
登録日1995-10-19
公開日1997-05-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin.
J.Mol.Biol., 255, 1996
1RSU
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BU of 1rsu by Molmil
COMPLEX BETWEEN STREPTAVIDIN AND THE STREP-TAG II PEPTIDE
分子名称: STREP-TAG II PEPTIDE, STREPTAVIDIN
著者Koepke, J, Schmidt, T, Skerra, A.
登録日1995-10-19
公開日1997-05-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin.
J.Mol.Biol., 255, 1996
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
分子名称: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
著者Eichinger, A, Skerra, A.
登録日2013-09-24
公開日2015-08-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016

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