8CUC
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3H7N
| Structure of Nup120 | 分子名称: | Nucleoporin NUP120 | 著者 | Seo, H.S, Ma, Y, Debler, E.W, Blobel, G, Hoelz, A. | 登録日 | 2009-04-27 | 公開日 | 2009-08-18 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc.Natl.Acad.Sci.USA, 106, 2009
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4MHC
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3F7F
| Structure of Nup120 | 分子名称: | MERCURY (II) ION, Nucleoporin NUP120 | 著者 | Seo, H.S, Ma, Y, Debler, E.W, Blobel, G, Hoelz, A. | 登録日 | 2008-11-08 | 公開日 | 2009-08-18 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc.Natl.Acad.Sci.USA, 106, 2009
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4MBR
| 3.65 Angstrom Crystal Structure of Serine-rich Repeat Protein (Srr2) from Streptococcus agalactiae | 分子名称: | Serine-rich repeat protein 2 | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Seo, H.S, Seepersaud, R, Doran, K.S, Iverson, T.M, Sullam, P.M, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-08-19 | 公開日 | 2013-11-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. J.Biol.Chem., 288, 2013
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4MBO
| 1.65 Angstrom Crystal Structure of Serine-rich Repeat Adhesion Glycoprotein (Srr1) from Streptococcus agalactiae | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-MERCAPTOETHANOL, CALCIUM ION, ... | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Seo, H.S, Seepersaud, R, Doran, K.S, Iverson, T.M, Sullam, P.M, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-08-19 | 公開日 | 2013-11-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. J.Biol.Chem., 288, 2013
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8ECM
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6MR4
| Crystal structure of the Sth1 bromodomain from S.cerevisiae | 分子名称: | Nuclear protein STH1/NPS1 | 著者 | Seo, H.S, Hashimoto, H, Krolak, A, Debler, E.W, Blus, B.J. | 登録日 | 2018-10-11 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Substrate Affinity and Specificity of the ScSth1p Bromodomain Are Fine-Tuned for Versatile Histone Recognition. Structure, 27, 2019
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6UCH
| SMARCB1 nucleosome-interacting C-terminal alpha helix | 分子名称: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | 著者 | Valencia, A.M, Sun, Z.Y.J, Seo, H.S, Vangos, H.S, Yeoh, Z.C, Mashtalir, N, Dhe-Paganon, S, Kadoch, C. | 登録日 | 2019-09-16 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell, 179, 2019
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4OWR
| Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair Rae1-Nup98 | 分子名称: | Matrix protein, Nuclear pore complex protein Nup98-Nup96, mRNA export factor | 著者 | Ren, Y, Quan, B, Seo, H.S, Blobel, G. | 登録日 | 2014-02-03 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 Nup98). Proc.Natl.Acad.Sci.USA, 111, 2014
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5WHH
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6DUN
| Crystal Structure Analysis of PIN1 | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III) | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2018-06-21 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun, 9, 2018
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6V4E
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6P38
| Crystal Structure Analysis of TAF1 Bromodomain | 分子名称: | 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide, Transcription initiation factor TFIID subunit 1 | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-05-23 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. Acs Med.Chem.Lett., 10, 2019
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6OSP
| Crystal Structure Analysis of PIP4K2A | 分子名称: | 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}-N-(3-{[6-(1H-indol-3-yl)pyrimidin-4-yl]amino}phenyl)benzamide, GLYCEROL, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-05-01 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol, 27, 2020
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7S7G
| Crystal Structure Analysis of Human VLCAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2021-09-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun, 13, 2022
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6UX9
| Crystal Structure Analysis of PIP4K2A | 分子名称: | N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-11-07 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J.Med.Chem., 63, 2020
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6V4G
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6VAJ
| Crystal Structure Analysis of human PIN1 | 分子名称: | 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ... | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-12-17 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat.Chem.Biol., 17, 2021
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6V4H
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6V4F
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6VO4
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6MBZ
| Structure of Transcription Factor | 分子名称: | Signal transducer and activator of transcription 5B | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2018-08-30 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Structural and functional consequences of the STAT5BN642Hdriver mutation. Nat Commun, 10, 2019
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5TWY
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5TWX
| Crystal Structure of BRD9 bromodomain | 分子名称: | Bromodomain-containing protein 9, N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2016-11-15 | 公開日 | 2017-09-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew. Chem. Int. Ed. Engl., 56, 2017
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