6UX9

Crystal Structure Analysis of PIP4K2A

Summary for 6UX9

Entry DOI	10.2210/pdb6ux9/pdb
Descriptor	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide (3 entities in total)
Functional Keywords	kinase, signaling protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	86490.21
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2019-11-07, release date: 2020-12-09, Last modification date: 2023-10-11)
Primary citation	Manz, T.D.,Sivakumaren, S.C.,Ferguson, F.M.,Zhang, T.,Yasgar, A.,Seo, H.S.,Ficarro, S.B.,Card, J.D.,Shim, H.,Miduturu, C.V.,Simeonov, A.,Shen, M.,Marto, J.A.,Dhe-Paganon, S.,Hall, M.D.,Cantley, L.C.,Gray, N.S. Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. J.Med.Chem., 63:4880-4895, 2020 Cited by PubMed: 32298120 DOI: 10.1021/acs.jmedchem.0c00227 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation