6UX9
Crystal Structure Analysis of PIP4K2A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | polymer | 370 | 42870.7 | 2 | UniProt (P48426) Pfam (PF01504) | Homo sapiens (Human) | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha,Diphosphoinositide kinase 2-alpha,PIP5KIII,Phosphatidylinositol 5-phosphate 4-kinase type II alpha,PIP4KII-alpha,PtdIns(4)P-5-kinase B isoform,PtdIns(4)P-5-kinase C isoform,PtdIns(5)P-4-kinase isoform 2-alpha |
| 2 | C, D (A, B) | N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide | non-polymer | 374.4 | 2 | Chemie (UHJ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 358 | Chemie (HOH) |
Sequence modifications
A, B: 35 - 405 (UniProt: P48426)
| PDB | External Database | Details |
|---|---|---|
| Met 12 | - | initiating methionine |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| Ser 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Gly 21 | - | expression tag |
| Val 22 | - | expression tag |
| Asp 23 | - | expression tag |
| Leu 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Thr 26 | - | expression tag |
| Glu 27 | - | expression tag |
| Asn 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Tyr 30 | - | expression tag |
| Phe 31 | - | expression tag |
| Gln 32 | - | expression tag |
| Ser 33 | - | expression tag |
| Met 34 | - | expression tag |
| - | Gly 298 | deletion |
| - | Glu 299 | deletion |
| - | Glu 300 | deletion |
| - | Glu 301 | deletion |
| - | Gly 302 | deletion |
| - | Glu 303 | deletion |
| - | Ser 304 | deletion |
| - | Asp 305 | deletion |
| - | Gly 306 | deletion |
| - | Thr 307 | deletion |
| - | His 308 | deletion |
| - | Pro 309 | deletion |
| - | Val 310 | deletion |
| - | Gly 311 | deletion |
| - | Thr 312 | deletion |
| - | Pro 313 | deletion |
| - | Pro 314 | deletion |
| - | Asp 315 | deletion |
| - | Ser 316 | deletion |
| - | Pro 317 | deletion |
| - | Gly 318 | deletion |
| - | Asn 319 | deletion |
| - | Thr 320 | deletion |
| - | Leu 321 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85741.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 748.9 | |
| All* | Total formula weight | 86490.2 |
