6UCH

SMARCB1 nucleosome-interacting C-terminal alpha helix

Summary for 6UCH

Entry DOI	10.2210/pdb6uch/pdb
NMR Information	BMRB: 30672
Descriptor	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (1 entity in total)
Functional Keywords	mswi-snf complex, baf complex, chromatin remodeling, smarcb1, baf47, positive charge cluster, arginine cluster, nucleosome binding, alpha helix, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	4748.47
Authors	Valencia, A.M.,Sun, Z.Y.J.,Seo, H.S.,Vangos, H.S.,Yeoh, Z.C.,Mashtalir, N.,Dhe-Paganon, S.,Kadoch, C. (deposition date: 2019-09-16, release date: 2019-11-27, Last modification date: 2019-12-11)
Primary citation	Valencia, A.M.,Collings, C.K.,Dao, H.T.,St Pierre, R.,Cheng, Y.C.,Huang, J.,Sun, Z.Y.,Seo, H.S.,Mashtalir, N.,Comstock, D.E.,Bolonduro, O.,Vangos, N.E.,Yeoh, Z.C.,Dornon, M.K.,Hermawan, C.,Barrett, L.,Dhe-Paganon, S.,Woolf, C.J.,Muir, T.W.,Kadoch, C. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell, 179:1342-1356.e23, 2019 Cited by PubMed: 31759698 DOI: 10.1016/j.cell.2019.10.044 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation