6P38

Crystal Structure Analysis of TAF1 Bromodomain

Summary for 6P38

• Entry DOI: 10.2210/pdb6p38/pdb
• Descriptor: Transcription initiation factor TFIID subunit 1, 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide (2 entities in total)
• Functional Keywords: kinase, bromodomain, inhibitor, transcription, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16417.51

Authors

Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2019-05-23, release date: 2020-05-27, Last modification date: 2023-10-11)

• Primary citation: Remillard, D.,Buckley, D.L.,Seo, H.S.,Ferguson, F.M.,Dhe-Paganon, S.,Bradner, J.E.,Gray, N.S.; Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.; Acs Med.Chem.Lett., 10:1443-1449, 2019; PubMed: 31620231; DOI: 10.1021/acsmedchemlett.9b00243

Experimental method

X-RAY DIFFRACTION (2.8 Å)