6DUN

Crystal Structure Analysis of PIN1

Summary for 6DUN

• Entry DOI: 10.2210/pdb6dun/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III) (3 entities in total)
• Functional Keywords: prolyl isomerase, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 27462.18

Authors

Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2018-06-21, release date: 2019-03-06, Last modification date: 2023-10-11)

• Primary citation: Kozono, S.,Lin, Y.M.,Seo, H.S.,Pinch, B.,Lian, X.,Qiu, C.,Herbert, M.K.,Chen, C.H.,Tan, L.,Gao, Z.J.,Massefski, W.,Doctor, Z.M.,Jackson, B.P.,Chen, Y.,Dhe-Paganon, S.,Lu, K.P.,Zhou, X.Z.; Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.; Nat Commun, 9:3069-3069, 2018; PubMed: 30093655; DOI: 10.1038/s41467-018-05402-2

Experimental method

X-RAY DIFFRACTION (1.59 Å)