6VO4

Crystal Structure Analysis of BFL1

Summary for 6VO4

Entry DOI	10.2210/pdb6vo4/pdb
Descriptor	Bcl-2-related protein A1 (2 entities in total)
Functional Keywords	bfl-1/a1, bcl-2 family, apoptosis, disulfide tethering, small molecule, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18596.06
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2020-01-29, release date: 2020-06-03, Last modification date: 2023-10-11)
Primary citation	Harvey, E.P.,Hauseman, Z.J.,Cohen, D.T.,Rettenmaier, T.J.,Lee, S.,Huhn, A.J.,Wales, T.E.,Seo, H.S.,Luccarelli, J.,Newman, C.E.,Guerra, R.M.,Bird, G.H.,Dhe-Paganon, S.,Engen, J.R.,Wells, J.A.,Walensky, L.D. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol, 27:647-, 2020 Cited by PubMed: 32413285 DOI: 10.1016/j.chembiol.2020.04.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation