6OSP

Crystal Structure Analysis of PIP4K2A

Summary for 6OSP

Entry DOI	10.2210/pdb6osp/pdb
Descriptor	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}-N-(3-{[6-(1H-indol-3-yl)pyrimidin-4-yl]amino}phenyl)benzamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	kinase, signaling protein, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	91713.41
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2019-05-01, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citation	Sivakumaren, S.C.,Shim, H.,Zhang, T.,Ferguson, F.M.,Lundquist, M.R.,Browne, C.M.,Seo, H.S.,Paddock, M.N.,Manz, T.D.,Jiang, B.,Hao, M.F.,Krishnan, P.,Wang, D.G.,Yang, T.J.,Kwiatkowski, N.P.,Ficarro, S.B.,Cunningham, J.M.,Marto, J.A.,Dhe-Paganon, S.,Cantley, L.C.,Gray, N.S. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol, 27:525-, 2020 Cited by PubMed: 32130941 DOI: 10.1016/j.chembiol.2020.02.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.21 Å)

Structure validation