2P5W
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![BU of 2p5w by Molmil](/molmil-images/mine/2p5w) | Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, CALCIUM ION, ... | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | 登録日 | 2007-03-16 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry Protein Eng.Des.Sel., 20, 2007
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2PYF
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![BU of 2pyf by Molmil](/molmil-images/mine/2pyf) | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry Unbound TCR Clone 5-1 | 分子名称: | SULFATE ION, T-Cell Receptor, Alpha Chain, ... | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | 登録日 | 2007-05-16 | 公開日 | 2007-09-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry Protein Eng.Des.Sel., 20, 2007
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2P5E
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![BU of 2p5e by Molmil](/molmil-images/mine/2p5e) | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native Diagonal Binding Geometry | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, Cancer/testis antigen 1B, ... | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | 登録日 | 2007-03-15 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry Protein Eng.Des.Sel., 20, 2007
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2PYE
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![BU of 2pye by Molmil](/molmil-images/mine/2pye) | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry TCR Clone C5C1 Complexed with MHC | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Beta-2-microglobulin, Cancer/testis antigen 1B, ... | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | 登録日 | 2007-05-16 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry Protein Eng.Des.Sel., 20, 2007
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7WT1
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![BU of 7wt1 by Molmil](/molmil-images/mine/7wt1) | |
7WT0
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![BU of 7wt0 by Molmil](/molmil-images/mine/7wt0) | human glyoxalase I (with C-ter His tag) in complex with TLSC702 | 分子名称: | (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid, Lactoylglutathione lyase, ZINC ION | 著者 | Usami, M, Yokoyama, H. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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7WSZ
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![BU of 7wsz by Molmil](/molmil-images/mine/7wsz) | human glyoxalase I (with C-ter His tag) in glycerol-bound form | 分子名称: | BETA-MERCAPTOETHANOL, BORIC ACID, GLYCEROL, ... | 著者 | Usami, M, Ando, K, Yokoyama, H. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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7WT2
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![BU of 7wt2 by Molmil](/molmil-images/mine/7wt2) | human glyoxalase I in complex with TLSC702 | 分子名称: | (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid, Lactoylglutathione lyase, ZINC ION | 著者 | Usami, M, Yokoyama, H. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett., 596, 2022
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6R2L
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![BU of 6r2l by Molmil](/molmil-images/mine/6r2l) | NYBR1-A2-SLSKILDTV | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ... | 著者 | Rizkallah, P.J, Cole, D.K, Sami, M. | 登録日 | 2019-03-18 | 公開日 | 2020-02-26 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | NYBR1-A2-SLSKILDTV To Be Published
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2F53
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![BU of 2f53 by Molmil](/molmil-images/mine/2f53) | Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity | 分子名称: | Beta-2-microglobulin, Cancer/testis antigen 1B, GLYCEROL, ... | 著者 | Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M. | 登録日 | 2005-11-25 | 公開日 | 2006-04-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci., 15, 2006
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5BS0
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![BU of 5bs0 by Molmil](/molmil-images/mine/5bs0) | MAGE-A3 Reactive TCR in complex with Titin Epitope in HLA-A1 | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | 著者 | Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, Lomax, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K. | 登録日 | 2015-06-01 | 公開日 | 2016-03-02 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Sci Rep, 6, 2016
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5BRZ
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![BU of 5brz by Molmil](/molmil-images/mine/5brz) | MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1 | 分子名称: | Beta-2-microglobulin, GLU-VAL-ASP-PRO-ILE-GLY-HIS-LEU-TYR, HLA class I histocompatibility antigen, ... | 著者 | Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donnellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, LomaX, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K. | 登録日 | 2015-06-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Sci Rep, 6, 2016
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2BNR
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![BU of 2bnr by Molmil](/molmil-images/mine/2bnr) | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ... | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | 登録日 | 2005-03-31 | 公開日 | 2005-05-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines J.Exp.Med., 201, 2005
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2BNU
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![BU of 2bnu by Molmil](/molmil-images/mine/2bnu) | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | 分子名称: | T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, Van Der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | 登録日 | 2005-04-04 | 公開日 | 2005-05-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines. J.Exp.Med., 201, 2005
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2BNQ
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![BU of 2bnq by Molmil](/molmil-images/mine/2bnq) | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ... | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | 登録日 | 2005-03-31 | 公開日 | 2005-05-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines J.Exp.Med., 201, 2005
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2BJS
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![BU of 2bjs by Molmil](/molmil-images/mine/2bjs) | Isopenicillin N synthase C-terminal truncation mutant | 分子名称: | FE (III) ION, ISOPENICILLIN N SYNTHETASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | 著者 | McNeill, L.A, Sami, M, Clifton, I.J, Burzlaff, N.I. | 登録日 | 2005-02-07 | 公開日 | 2006-03-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases. Chemistry, 23, 2017
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2F54
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![BU of 2f54 by Molmil](/molmil-images/mine/2f54) | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity | 分子名称: | Beta-2-microglobulin, Cancer/testis antigen 1B, HLA class I histocompatibility antigen, ... | 著者 | Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M. | 登録日 | 2005-11-25 | 公開日 | 2006-04-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci., 15, 2006
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2HP4
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![BU of 2hp4 by Molmil](/molmil-images/mine/2hp4) | Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor | 分子名称: | GLYCEROL, SULFATE ION, T-cell surface glycoprotein CD8 alpha chain | 著者 | Rizkallah, P.J, Cole, D.K, Jakobsen, B.K, Boulter, J.M, Glick, M, Gao, G.F. | 登録日 | 2006-07-17 | 公開日 | 2007-02-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor Proteins, 67, 2007
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6RSY
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![BU of 6rsy by Molmil](/molmil-images/mine/6rsy) | |
6EQB
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![BU of 6eqb by Molmil](/molmil-images/mine/6eqb) | HLA class I histocompatibility antigen | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, ... | 著者 | Rizkallah, P.J, Cole, D.K. | 登録日 | 2017-10-12 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | TCR-induced alteration of primary MHC peptide anchor residue. Eur.J.Immunol., 49, 2019
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6EQA
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![BU of 6eqa by Molmil](/molmil-images/mine/6eqa) | HLA class I histocompatibility antigen | 分子名称: | ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | 著者 | Rizkallah, P.J, Cole, D.K. | 登録日 | 2017-10-12 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | TCR-induced alteration of primary MHC peptide anchor residue. Eur.J.Immunol., 49, 2019
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4JFP
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![BU of 4jfp by Molmil](/molmil-images/mine/4jfp) | A2 HLA complex with G4A heteroclitic variant of Melanoma peptide | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ... | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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4JFO
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![BU of 4jfo by Molmil](/molmil-images/mine/4jfo) | A2 HLA complex with E1A heteroclitic variant of Melanoma peptide | 分子名称: | Beta-2-microglobulin, E1A heteroclitic Melanoma peptide, GLYCEROL, ... | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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4JFH
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![BU of 4jfh by Molmil](/molmil-images/mine/4jfh) | High Affinity alpha24-beta17 T Cell Receptor for A2 HLA-Melanoma peptide complex | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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4JFD
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![BU of 4jfd by Molmil](/molmil-images/mine/4jfd) | Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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