Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5K1V
DownloadVisualize
BU of 5k1v by Molmil
Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ...
著者Saridakis, E, Papakyriakou, A, Giastas, P, Mpakali, A, Mavridis, I.M, Stratikos, E.
登録日2016-05-18
公開日2017-03-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.897 Å)
主引用文献Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
ACS Med Chem Lett, 8, 2017
2HU6
DownloadVisualize
BU of 2hu6 by Molmil
Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
分子名称: (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE, ACETOHYDROXAMIC ACID, CALCIUM ION, ...
著者Mannino, C, Nievo, M, Machetti, F, Papakyriakou, A, Calderone, V, Fragai, M, Guarna, A.
登録日2006-07-26
公開日2006-12-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.
Bioorg.Med.Chem., 14, 2006
7ZYF
DownloadVisualize
BU of 7zyf by Molmil
Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mpakali, A, Stratikos, E, Giastas, P, Papakyriakou, A.
登録日2022-05-24
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
J.Med.Chem., 65, 2022
7Z28
DownloadVisualize
BU of 7z28 by Molmil
High-resolution crystal structure of ERAP1 with bound bestatin analogue inhibitor
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Giastas, P, Papakyriakou, A, Stratikos, E, Vourloumis, D.
登録日2022-02-26
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
J.Med.Chem., 65, 2022
6TVL
DownloadVisualize
BU of 6tvl by Molmil
Hen Egg White Lysozyme in complex with a "half sandwich"-type Ru(II) coordination compound
分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-01-10
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.395 Å)
主引用文献High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K.
J.Biol.Inorg.Chem., 25, 2020
6TXG
DownloadVisualize
BU of 6txg by Molmil
Proteinase K in complex with a "half sandwich"-type Ru(II) coordination compound
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, NITRATE ION, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-01-14
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.372 Å)
主引用文献High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K.
J.Biol.Inorg.Chem., 25, 2020
7BCX
DownloadVisualize
BU of 7bcx by Molmil
The adduct of NAMI-A with Hen Egg White Lysozyme at 8 hours.
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, IMIDAZOLE, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-12-21
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.06 Å)
主引用文献Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Inorg.Chem., 60, 2021
7BDM
DownloadVisualize
BU of 7bdm by Molmil
The adduct of NAMI-A with Hen Egg White Lysozyme at 98 hours.
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-12-22
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Inorg.Chem., 60, 2021
7BD0
DownloadVisualize
BU of 7bd0 by Molmil
The adduct of NAMI-A with Hen Egg White Lysozyme at 26 hours.
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-12-21
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.06 Å)
主引用文献Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Inorg.Chem., 60, 2021
7BCU
DownloadVisualize
BU of 7bcu by Molmil
The adduct of NAMI-A with Hen Egg White Lysozyme at 1.5 hours.
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, IMIDAZOLE, ...
著者Chiniadis, L, Giastas, P, Bratsos, I, Papakyriakou, A.
登録日2020-12-21
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Inorg.Chem., 60, 2021
5OQG
DownloadVisualize
BU of 5oqg by Molmil
Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb W167A, beta-2microglobulin, and and ovalbumin-derived peptide.
分子名称: Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
著者Mikolajek, H, Werner, J.M.
登録日2017-08-11
公開日2018-04-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQH
DownloadVisualize
BU of 5oqh by Molmil
Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2Kb Y84C K66A mutant, beta-2microglobulin, and ovalbumin-derived peptide
分子名称: Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
著者Mikolajek, H, Werner, J.M, Beton, M.E.
登録日2017-08-11
公開日2018-04-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQF
DownloadVisualize
BU of 5oqf by Molmil
Crystal structure of a single chain trimer composed of the MHC 1 heavy chain H2-Kb WT, beta-2microglobulin, and ovalbumin derived peptide
分子名称: Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
著者Mikolajek, H, Werner, J.M.
登録日2017-08-11
公開日2018-04-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQI
DownloadVisualize
BU of 5oqi by Molmil
Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2Kb Y84C E63A mutant, beta-2microglobulin, and ovalbumin-derived peptide
分子名称: Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
著者Mikolajek, H, Werner, J.M, Beton, M.E.
登録日2017-08-11
公開日2018-04-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
6SEQ
DownloadVisualize
BU of 6seq by Molmil
Lemur tyrosine kinase 3 (LMTK3)
分子名称: Serine/threonine-protein kinase LMTK3
著者Roe, S.M, Owen, R.
登録日2019-07-30
公開日2020-11-25
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structure-function relationship of oncogenic LMTK3.
Sci Adv, 6, 2020
5MJ6
DownloadVisualize
BU of 5mj6 by Molmil
Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ...
著者Mpakali, A, Stratikos, E, Saridakis, E, Giastas, P.
登録日2016-11-30
公開日2017-04-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
J. Med. Chem., 60, 2017
5J6S
DownloadVisualize
BU of 5j6s by Molmil
Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
分子名称: (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E.
登録日2016-04-05
公開日2017-03-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
ACS Med Chem Lett, 8, 2017
5C97
DownloadVisualize
BU of 5c97 by Molmil
Insulin regulated aminopeptidase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ...
著者Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E.
登録日2015-06-26
公開日2015-08-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.37 Å)
主引用文献Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
J Immunol., 195, 2015
4Z7I
DownloadVisualize
BU of 4z7i by Molmil
Crystal structure of insulin regulated aminopeptidase in complex with ligand
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ...
著者Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E.
登録日2015-04-07
公開日2015-08-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
J Immunol., 195, 2015
6HBY
DownloadVisualize
BU of 6hby by Molmil
HLA class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
分子名称: 1,2-ETHANEDIOL, ARRPPLAELAALNLSGSRL 5T4 tumour epitope, HLA class II histocompatibility antigen, ...
著者MacLachlan, B, Rizkallah, P.J, Sewell, A.K, Cole, D.K, Godkin, A.J.
登録日2018-08-13
公開日2019-08-14
最終更新日2020-01-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.
J.Biol.Chem., 294, 2019
4E36
DownloadVisualize
BU of 4e36 by Molmil
Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Birtley, J.R, Saridakis, E, Pegias, P, Stratikos, E, Mavridis, I.M.
登録日2012-03-09
公開日2012-08-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
J.Immunol., 189, 2012
6RQX
DownloadVisualize
BU of 6rqx by Molmil
High-resolution crystal structure of ERAP1 in complex with 10mer phosphinic peptide
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Giastas, P, Stratikos, E.
登録日2019-05-16
公開日2019-12-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Proc.Natl.Acad.Sci.USA, 2019
6RYF
DownloadVisualize
BU of 6ryf by Molmil
High-resolution crystal structure of ERAP1 in complex with 15mer phosphinic peptide
分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Giastas, P, Stratikos, E.
登録日2019-06-10
公開日2019-12-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Proc.Natl.Acad.Sci.USA, 2019
6HY7
DownloadVisualize
BU of 6hy7 by Molmil
Crystal structure of alpha9 nAChR extracellular domain in complex with alpha-conotoxin RgIA
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-conotoxin RgIA, ...
著者Giastas, P, Zouridakis, M.
登録日2018-10-19
公開日2019-05-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal Structure of the Monomeric Extracellular Domain of alpha 9 Nicotinic Receptor Subunit in Complex With alpha-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to alpha 9 alpha 10 Nicotinic Receptors.
Front Pharmacol, 10, 2019
4HJ2
DownloadVisualize
BU of 4hj2 by Molmil
Crystal Structure Analysis of GSTA1-1 in complex with chlorambucil
分子名称: Glutathione S-transferase A1, L-gamma-glutamyl-S-(2-{[4-(3-carboxypropyl)phenyl](2-chloroethyl)amino}ethyl)-L-cysteinylglycine
著者Karpusas, M, Chiniadis, L, Labrou, N.E.
登録日2012-10-12
公開日2013-03-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis.
Plos One, 8, 2013

 

12>

221716

件を2024-06-26に公開中

PDB statisticsPDBj update infoContact PDBjnumon