6HBY

HLA class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

Summary for 6HBY

Entry DOI	10.2210/pdb6hby/pdb
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, ARRPPLAELAALNLSGSRL 5T4 tumour epitope, ... (7 entities in total)
Functional Keywords	hla class ii, mhc ii, human, 5t4 tumor epitope, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	92166.05
Authors	MacLachlan, B.,Rizkallah, P.J.,Sewell, A.K.,Cole, D.K.,Godkin, A.J. (deposition date: 2018-08-13, release date: 2019-08-14, Last modification date: 2020-01-29)
Primary citation	MacLachlan, B.J.,Dolton, G.,Papakyriakou, A.,Greenshields-Watson, A.,Mason, G.H.,Schauenburg, A.,Besneux, M.,Szomolay, B.,Elliott, T.,Sewell, A.K.,Gallimore, A.,Rizkallah, P.,Cole, D.K.,Godkin, A. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. J.Biol.Chem., 294:20246-20258, 2019 Cited by PubMed: 31619516 DOI: 10.1074/jbc.RA119.009437 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation