6HBY
HLA class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 178 | 20727.4 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (Human) | MHC class II antigen DRA |
| 2 | B, E (B, E) | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 191 | 22211.9 | 2 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (Human) | MHC class II antigen DRB1*1,DR1 |
| 3 | C, F (C, F) | ARRPPLAELAALNLSGSRL 5T4 tumour epitope | polymer | 19 | 2008.4 | 2 | UniProt (by SIFTS) (Q13641) | Homo sapiens | |
| 4 | D (D) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 180 | 20971.7 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (Human) | MHC class II antigen DRA |
| 5 | AA, BA, CA, DA, EA... (D, E, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 25 | Chemie (EDO) | |||
| 6 | IA, JA, L, X, Y (E, A, B) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 7 | KA, LA, MA, NA, OA... (A, B, C, D, E...) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 190 (UniProt: P04229)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 90139.5 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 2026.6 | |
| All* | Total formula weight | 92166.0 |
