2HU6
Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
Summary for 2HU6
Entry DOI | 10.2210/pdb2hu6/pdb |
Related | 1RMZ 1Y93 |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | mmp-12, matrix metalloproteinase, macrophage metalloelastase, inhibitor, hydroxamic acid, drug design, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 1 |
Total formula weight | 18325.19 |
Authors | Mannino, C.,Nievo, M.,Machetti, F.,Papakyriakou, A.,Calderone, V.,Fragai, M.,Guarna, A. (deposition date: 2006-07-26, release date: 2006-12-19, Last modification date: 2023-08-30) |
Primary citation | Mannino, C.,Nievo, M.,Machetti, F.,Papakyriakou, A.,Calderone, V.,Fragai, M.,Guarna, A. Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors. Bioorg.Med.Chem., 14:7392-7403, 2006 Cited by PubMed: 16899369DOI: 10.1016/j.bmc.2006.07.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
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