1Y93
Crystal structure of the catalytic domain of human MMP12 complexed with acetohydroxamic acid at atomic resolution
Summary for 1Y93
Entry DOI | 10.2210/pdb1y93/pdb |
Related | 1JK3 1OS2 1OS9 1RMZ |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, acetohydroxamic acid, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P39900 |
Total number of polymer chains | 1 |
Total formula weight | 17941.79 |
Authors | Bertini, I.,Calderone, V.,Cosenza, M.,Fragai, M.,Lee, Y.-M.,Luchinat, C.,Mangani, S.,Terni, B.,Turano, P. (deposition date: 2004-12-14, release date: 2005-04-26, Last modification date: 2023-08-23) |
Primary citation | Bertini, I.,Calderone, V.,Cosenza, M.,Fragai, M.,Lee, Y.-M.,Luchinat, C.,Mangani, S.,Terni, B.,Turano, P. Conformational variability of matrix metalloproteinases: Beyond a single 3D structure Proc.Natl.Acad.Sci.Usa, 102:5334-5339, 2005 Cited by PubMed: 15809432DOI: 10.1073/pnas.0407106102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.03 Å) |
Structure validation
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