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1Y93

Crystal structure of the catalytic domain of human MMP12 complexed with acetohydroxamic acid at atomic resolution

Summary for 1Y93
Entry DOI10.2210/pdb1y93/pdb
Related1JK3 1OS2 1OS9 1RMZ
DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmatrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, acetohydroxamic acid, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains1
Total formula weight17941.79
Authors
Bertini, I.,Calderone, V.,Cosenza, M.,Fragai, M.,Lee, Y.-M.,Luchinat, C.,Mangani, S.,Terni, B.,Turano, P. (deposition date: 2004-12-14, release date: 2005-04-26, Last modification date: 2023-08-23)
Primary citationBertini, I.,Calderone, V.,Cosenza, M.,Fragai, M.,Lee, Y.-M.,Luchinat, C.,Mangani, S.,Terni, B.,Turano, P.
Conformational variability of matrix metalloproteinases: Beyond a single 3D structure
Proc.Natl.Acad.Sci.Usa, 102:5334-5339, 2005
Cited by
PubMed: 15809432
DOI: 10.1073/pnas.0407106102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.03 Å)
Structure validation

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