Crystal structure of alpha9 nAChR extracellular domain in complex with alpha-conotoxin RgIA

Summary for 6HY7

DescriptorNeuronal acetylcholine receptor subunit alpha-9, Alpha-conotoxin RgIA, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsalpha9, ion channel, nachr, acetylcholine, conotoxin, rgia, antagonist, toxin
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight27389.4
Giastas, P.,Zouridakis, M. (deposition date: 2018-10-19, release date: 2019-05-22, Last modification date: 2019-06-05)
Primary citation
Zouridakis, M.,Papakyriakou, A.,Ivanov, I.A.,Kasheverov, I.E.,Tsetlin, V.,Tzartos, S.,Giastas, P.
Crystal Structure of the Monomeric Extracellular Domain of alpha 9 Nicotinic Receptor Subunit in Complex With alpha-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to alpha 9 alpha 10 Nicotinic Receptors.
Front Pharmacol, 10:474-474, 2019
PubMed: 31118896 (PDB entries with the same primary citation)
DOI: 10.3389/fphar.2019.00474
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24714 0.9% 1.5% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6hy7
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Molmil generated image of 6hy7
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Molmil generated image of 6hy7
rotated about y axis by 90°