4PH9
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![BU of 4ph9 by Molmil](/molmil-images/mine/4ph9) | The structure of Ibuprofen bound to cyclooxygenase-2 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Orlando, B.J, Lucido, M.J, Malkowski, M.G. | 登録日 | 2014-05-05 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | The structure of ibuprofen bound to cyclooxygenase-2. J.Struct.Biol., 189, 2015
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5KIR
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![BU of 5kir by Molmil](/molmil-images/mine/5kir) | |
5IKQ
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![BU of 5ikq by Molmil](/molmil-images/mine/5ikq) | |
5IKV
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![BU of 5ikv by Molmil](/molmil-images/mine/5ikv) | |
5IKR
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5IKT
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![BU of 5ikt by Molmil](/molmil-images/mine/5ikt) | The Structure of Tolfenamic Acid Bound to Human Cyclooxygenase-2 | 分子名称: | 2-[(3-chloro-2-methylphenyl)amino]benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Orlando, B.J, Malkowski, M.G. | 登録日 | 2016-03-03 | 公開日 | 2016-05-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.451 Å) | 主引用文献 | Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291, 2016
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6VXI
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![BU of 6vxi by Molmil](/molmil-images/mine/6vxi) | Structure of ABCG2 bound to mitoxantrone | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL | 著者 | Orlando, B.J, Liao, M. | 登録日 | 2020-02-21 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
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6VXH
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![BU of 6vxh by Molmil](/molmil-images/mine/6vxh) | Structure of ABCG2 bound to imatinib | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL | 著者 | Orlando, B.J, Liao, M. | 登録日 | 2020-02-21 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
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6VXF
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![BU of 6vxf by Molmil](/molmil-images/mine/6vxf) | Structure of apo-closed ABCG2 | 分子名称: | Broad substrate specificity ATP-binding cassette transporter ABCG2 | 著者 | Orlando, B.J, Maofu, L. | 登録日 | 2020-02-21 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
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6VXJ
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![BU of 6vxj by Molmil](/molmil-images/mine/6vxj) | Structure of ABCG2 bound to SN38 | 分子名称: | 7-ethyl-10-hydroxycamptothecin, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL | 著者 | Orlando, B.J, Liao, M. | 登録日 | 2020-02-22 | 公開日 | 2020-05-13 | 最終更新日 | 2020-05-20 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
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5JVY
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![BU of 5jvy by Molmil](/molmil-images/mine/5jvy) | Crystal structure of S121P murine COX-2 mutant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ... | 著者 | Orlando, B.J, Malkowski, M.G, Dong, L. | 登録日 | 2016-05-11 | 公開日 | 2016-10-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291, 2016
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6MHU
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![BU of 6mhu by Molmil](/molmil-images/mine/6mhu) | Nucleotide-free Cryo-EM Structure of E.coli LptB2FG Transporter | 分子名称: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | 著者 | Orlando, B.J, Li, Y, Liao, M. | 登録日 | 2018-09-18 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
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6MI8
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![BU of 6mi8 by Molmil](/molmil-images/mine/6mi8) | Cryo-EM Structure of vanadate-trapped E.coli LptB2FGC | 分子名称: | ADP ORTHOVANADATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | 著者 | Orlando, B.J, Li, Y, Liao, M. | 登録日 | 2018-09-19 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
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6NJ8
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![BU of 6nj8 by Molmil](/molmil-images/mine/6nj8) | Encapsulin iron storage compartment from Quasibacillus thermotolerans | 分子名称: | Encapsulating protein for a DyP-type peroxidase, targeting peptide | 著者 | Orlando, B.J, Giessen, T.W, Chambers, M.G, Liao, M, Silver, P.A. | 登録日 | 2019-01-02 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Large protein organelles form a new iron sequestration system with high storage capacity. Elife, 8, 2019
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6MHZ
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![BU of 6mhz by Molmil](/molmil-images/mine/6mhz) | Vanadate trapped Cryo-EM Structure of E.coli LptB2FG Transporter | 分子名称: | ADP ORTHOVANADATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | 著者 | Orlando, B.J, Li, Y, Liao, M. | 登録日 | 2018-09-18 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
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6MI7
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![BU of 6mi7 by Molmil](/molmil-images/mine/6mi7) | Nucleotide-free Cryo-EM Structure of E.coli LptB2FGC | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | 著者 | Orlando, B.J, Li, Y, Liao, M. | 登録日 | 2018-09-19 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
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5JW1
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![BU of 5jw1 by Molmil](/molmil-images/mine/5jw1) | Crystal structure of Celecoxib bound to S121P murine COX-2 mutant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, ... | 著者 | Malkowski, M.G, Orlando, B.J. | 登録日 | 2016-05-11 | 公開日 | 2016-10-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.822 Å) | 主引用文献 | Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J.Biol.Chem., 291, 2016
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5F19
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![BU of 5f19 by Molmil](/molmil-images/mine/5f19) | The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lucido, M.J, Orlando, B.J, Malkowski, M.G. | 登録日 | 2015-11-30 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
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5F1A
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![BU of 5f1a by Molmil](/molmil-images/mine/5f1a) | The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2 | 分子名称: | 1,2-ETHANEDIOL, 2-HYDROXYBENZOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lucido, M.J, Orlando, B.J, Malkowski, M.G. | 登録日 | 2015-11-30 | 公開日 | 2016-03-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
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5FDQ
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![BU of 5fdq by Molmil](/molmil-images/mine/5fdq) | Murine COX-2 S530T mutant | 分子名称: | 2-[(2~{R})-2-(hydroxymethyloxy)propoxy]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lucido, M.J, Orlando, B.J, Malkowski, M.G. | 登録日 | 2015-12-16 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
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7TCH
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![BU of 7tch by Molmil](/molmil-images/mine/7tch) | BceAB E169Q variant ATP-bound conformation | 分子名称: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, ADENOSINE-5'-TRIPHOSPHATE, Bacitracin export ATP-binding protein BceA, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2021-12-23 | 公開日 | 2022-04-06 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TCG
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![BU of 7tcg by Molmil](/molmil-images/mine/7tcg) | BceAB nucleotide-free conformation | 分子名称: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2021-12-23 | 公開日 | 2022-04-06 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB. Proc.Natl.Acad.Sci.USA, 119, 2022
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5JVZ
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![BU of 5jvz by Molmil](/molmil-images/mine/5jvz) | |
8G3F
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![BU of 8g3f by Molmil](/molmil-images/mine/8g3f) | BceAB-S nucleotide free BceS state 1 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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8G3B
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![BU of 8g3b by Molmil](/molmil-images/mine/8g3b) | BceAB-S nucleotide free TM state 2 | 分子名称: | Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... | 著者 | George, N.L, Orlando, B.J. | 登録日 | 2023-02-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
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