The Structure of Mefenamic Acid Bound to Human Cyclooxygenase-2

Summary for 5IKR

Related5IKT 5IKQ 5IKV
DescriptorProstaglandin G/H synthase 2, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, PROTOPORPHYRIN IX CONTAINING CO, ... (8 entities in total)
Functional Keywordscox mefenamic, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationMicrosome membrane; Peripheral membrane protein P35354
Total number of polymer chains2
Total molecular weight131519.62
Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-03-03, release date: 2016-05-25, Last modification date: 2017-09-27)
Primary citation
Orlando, B.J.,Malkowski, M.G.
Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.
J.Biol.Chem., 291:15069-15081, 2016
PubMed: 27226593 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.725713
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21330.1%2.0%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution