The Structure of Mefenamic Acid Bound to Human Cyclooxygenase-2

Summary for 5IKR

Related5IKT 5IKQ 5IKV
DescriptorProstaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, ... (8 entities in total)
Functional Keywordscox mefenamic, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight131447.56
Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-03-03, release date: 2016-05-25, Last modification date: 2020-07-29)
Primary citation
Orlando, B.J.,Malkowski, M.G.
Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.
J.Biol.Chem., 291:15069-15081, 2016
PubMed: 27226593 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.725713
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2133 0.1% 2.0% 3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21