5IKR
The Structure of Mefenamic Acid Bound to Human Cyclooxygenase-2
Summary for 5IKR
Entry DOI | 10.2210/pdb5ikr/pdb |
Related | 5IKQ 5IKT 5IKV |
Descriptor | Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, ... (8 entities in total) |
Functional Keywords | cox mefenamic, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 131447.56 |
Authors | Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-03-03, release date: 2016-05-25, Last modification date: 2020-07-29) |
Primary citation | Orlando, B.J.,Malkowski, M.G. Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291:15069-15081, 2016 Cited by PubMed: 27226593DOI: 10.1074/jbc.M116.725713 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.342 Å) |
Structure validation
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