5IKQ

The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2

Summary for 5IKQ

Entry DOI	10.2210/pdb5ikq/pdb
Related	5IKR 5IKT 5IKV
Descriptor	Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (8 entities in total)
Functional Keywords	cox meclofenamic, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	131572.87
Authors	Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-03-03, release date: 2016-05-25, Last modification date: 2020-07-29)
Primary citation	Orlando, B.J.,Malkowski, M.G. Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291:15069-15081, 2016 Cited by PubMed: 27226593 DOI: 10.1074/jbc.M116.725713 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation