5X08
| Crystal structure of broadly neutralizing anti-HIV-1 antibody 4E10, mutant Npro, with peptide bound | 分子名称: | ACETATE ION, CHLORIDE ION, Envelope glycoprotein gp160, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K. | 登録日 | 2017-01-20 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Functional Contacts between MPER and the Anti-HIV-1 Broadly Neutralizing Antibody 4E10 Extend into the Core of the Membrane J. Mol. Biol., 429, 2017
|
|
3EGS
| Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 scrambledFP-MPER scrHyb3K construct GIGAFGLLGFLAAGSKK-Ahx-K656NEQELLELDKWASLWN671 soaked in ammonium sulfate | 分子名称: | 2F5 Fab' heavy chain, 2F5 Fab' light chain, gp41 scrFP-MPER construct | 著者 | Julien, J.-P, Bryson, S, de la Torre, B.G, Andreu, D, Nieva, J.L, Pai, E.F. | 登録日 | 2008-09-11 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J.Phys.Chem.B, 113, 2009
|
|
3DRT
| Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 scrambledFP-MPER scrHyb3K construct GIGAFGLLGFLAAGSKK-Ahx-K656NEQELLELDKWASLWN671 | 分子名称: | 2F5 Fab' heavy chain, 2F5 Fab' light chain, GLYCEROL, ... | 著者 | Julien, J.-P, Bryson, S, de la Torre, B.G, Andreu, D, Nieva, J.L, Pai, E.F. | 登録日 | 2008-07-11 | 公開日 | 2009-06-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J.Phys.Chem.B, 113, 2009
|
|
7EKB
| Crystal structure of 4E10 modified with pyrene acetamide | 分子名称: | ACETATE ION, Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | 登録日 | 2021-04-05 | 公開日 | 2021-08-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
|
|
7EKK
| Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide | 分子名称: | AMMONIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | 登録日 | 2021-04-05 | 公開日 | 2021-08-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
|
|
5GHW
| Crystal structure of broad neutralizing antibody 10E8 with long epitope bound | 分子名称: | Endogenous retrovirus group K member 8 Env polyprotein, FAB 10E8 HEAVY CHAIN, FAB 10E8 LIGHT CHAIN, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Morante, K, Nieva, J.L, Tsumoto, K. | 登録日 | 2016-06-21 | 公開日 | 2016-11-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface Sci Rep, 6, 2016
|
|
4WY7
| Crystal structure of recombinant 4E10 expressed in Escherichia coli with epitope bound | 分子名称: | Envelope glycoprotein gp160, Fab 4E10 Heavy chain, Fab 4E10Light chain, ... | 著者 | Rujas, E, Morante, K, Tsumoto, K, Nieva, J.L, Caaveiro, J.M.M. | 登録日 | 2014-11-16 | 公開日 | 2015-03-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
|
|
8B6X
| |
8B6Y
| |
2M8O
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in DPC | 分子名称: | Transmembrane protein gp41 | 著者 | Serrano, S, Huarte, N, Nieva, J.L, Jimenez, M. | 登録日 | 2013-05-23 | 公開日 | 2014-01-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope: IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN. J.Biol.Chem., 289, 2014
|
|
5CIL
| Crystal Structure of non-neutralizing version of 4E10 (WDWD) with epitope bound | 分子名称: | ACETATE ION, CHLORIDE ION, FAB 4E10 HEAVY CHAIN, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K. | 登録日 | 2015-07-13 | 公開日 | 2015-09-23 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10 J.Virol., 89, 2015
|
|
5CIP
| Crystal Structure of Unbound 4E10 | 分子名称: | FAB 4E10 HEAVY CHAIN, FAB 4E10 LIGHT CHAIN | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K. | 登録日 | 2015-07-13 | 公開日 | 2015-09-23 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10 J.Virol., 89, 2015
|
|
5CIN
| Crystal Structure of non-neutralizing version of 4E10 (DeltaLoop) with epitope bound | 分子名称: | CHLORIDE ION, FAB 4E10 HEAVY CHAIN, FAB 4E10 LIGHT CHAIN, ... | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K. | 登録日 | 2015-07-13 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10 J.Virol., 89, 2015
|
|
2M8M
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol | 分子名称: | Transmembrane protein gp41 | 著者 | Serrano, S, Huarte, N, Nieva, J.L, Jimenez, M. | 登録日 | 2013-05-23 | 公開日 | 2014-01-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope: IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN. J.Biol.Chem., 289, 2014
|
|
2MG1
| NMR assignment and structure of a peptide derived from the trans-membrane region of HIV-1 gp41 in the presence of hexafluoroisopropanol | 分子名称: | Transmembrane protein gp41 | 著者 | Serrano, S, Apellaniz, B, Huarte, N.L, Nieva, J.L, Jimenez, M.A. | 登録日 | 2013-10-24 | 公開日 | 2015-03-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
|
|
2MG2
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol | 分子名称: | Transmembrane protein gp41 | 著者 | Serrano, S, Apellaniz, B, Huarte, N.L, Nieva, J.L, Jimenez, M.A. | 登録日 | 2013-10-24 | 公開日 | 2015-03-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
|
|
5NWU
| NMR assignment and structure of a peptide derived from the fusion peptide of HIV-1 gp41 in the presence of hexafluoroisopropanol | 分子名称: | wtFP-tag,Gp41 | 著者 | Jimenez, M.A, Serrano, S, Nieva, J.L, Huarte, N. | 登録日 | 2017-05-08 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance. Biochemistry, 56, 2017
|
|
5NWV
| NMR assignment and structure of a peptide derived from the fusion peptide of HIV-1 gp41 in the presence of dodecylphosphocholine micelles | 分子名称: | scrFP-tag,Gp41 | 著者 | Jimenez, M.A, Serrano, S, Nieva, J.L, Huarte, N. | 登録日 | 2017-05-08 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance. Biochemistry, 56, 2017
|
|
5NVP
| NMR assignment and structure of a peptide derived from the fusion peptide of HIV-1 gp41 in the presence of dodecylphosphocholine micelles | 分子名称: | Envelope glycoprotein,Gp41 | 著者 | Jimenez, M.A, Serrano, S, Nieva, J.L, Huarte, N. | 登録日 | 2017-05-04 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance. Biochemistry, 56, 2017
|
|
5NWW
| NMR assignment and structure of a peptide derived from the fusion peptide of HIV-1 gp41 in the presence of dodecylphosphocholine micelles | 分子名称: | scrFP-tag,Gp41 | 著者 | Jimenez, M.A, Serrano, S, Nieva, J.L, Huarte, N. | 登録日 | 2017-05-08 | 公開日 | 2017-12-06 | 最終更新日 | 2024-10-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance. Biochemistry, 56, 2017
|
|
2MG3
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of dodecylphosphocholine micelles | 分子名称: | Envelope glycoprotein gp41 | 著者 | Serrano, S, Apellaniz, B, Huarte, N, Nieva, J.L, Jimenez, M.A. | 登録日 | 2013-10-24 | 公開日 | 2015-03-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region. J.Biol.Chem., 290, 2015
|
|
2NCS
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of dodecylphosphocholine micelles | 分子名称: | Envelope glycoprotein gp41 | 著者 | Jimenez, M, Nieva, J.L, Rujas, E, Partida-Hanon, A, Bruix, M. | 登録日 | 2016-04-14 | 公開日 | 2017-02-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface. Sci Rep, 6, 2016
|
|
2NCT
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol | 分子名称: | Envelope glycoprotein gp41 | 著者 | Jimenez, M, Nieva, J.L, Rujas, E, Partida-Hanon, A, Bruix, M. | 登録日 | 2016-04-14 | 公開日 | 2017-02-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface. Sci Rep, 6, 2016
|
|
3DRQ
| Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 soaked in PEG/2-propanol solution | 分子名称: | 2F5 Fab' heavy chain, 2F5 Fab' light chain, GLYCEROL, ... | 著者 | Bryson, S, Julien, J.P, Pai, E.F. | 登録日 | 2008-07-11 | 公開日 | 2008-10-07 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site. J.Mol.Biol., 384, 2008
|
|
7AEJ
| |