4WY7

Crystal structure of recombinant 4E10 expressed in Escherichia coli with epitope bound

Summary for 4WY7

• Entry DOI: 10.2210/pdb4wy7/pdb
• Related: 2FX7
• Descriptor: Fab 4E10 Heavy chain, Fab 4E10Light chain, Envelope glycoprotein gp160, ... (5 entities in total)
• Functional Keywords: broad neutralizing antobody, recombinant fab, epitope, immune system
• Biological source: Homo sapiens; More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P05880
• Total number of polymer chains: 3
• Total formula weight: 49654.50

Authors

Rujas, E.,Morante, K.,Tsumoto, K.,Nieva, J.L.,Caaveiro, J.M.M. (deposition date: 2014-11-16, release date: 2015-03-25, Last modification date: 2024-01-10)

• Primary citation: Apellaniz, B.,Rujas, E.,Serrano, S.,Morante, K.,Tsumoto, K.,Caaveiro, J.M.,Jimenez, M.A.,Nieva, J.L.; The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region.; J.Biol.Chem., 290:12999-13015, 2015; PubMed: 25787074; DOI: 10.1074/jbc.M115.644351

Experimental method

X-RAY DIFFRACTION (2.1 Å)