7EKK
Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide
Summary for 7EKK
Entry DOI | 10.2210/pdb7ekk/pdb |
Descriptor | Heavy chain of the Fab region of Delta-loop variant of anti-HIV-1 broadly neutralizing antibody 4E10 modified with pyrene acetamide, Light chain of the Fab region of Delta-loop variant of anti-HIV-1 broadly neutralizing antibody 4E10 modified with pyrene acetamide, MPER region of the envelope glycoprotein gp41 from HIV-1, ... (8 entities in total) |
Functional Keywords | igg, fab, chemical modification, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 49162.34 |
Authors | Caaveiro, J.M.M.,Rujas, E.,Nieva, J.L. (deposition date: 2021-04-05, release date: 2021-08-11, Last modification date: 2023-11-29) |
Primary citation | Rujas, E.,Leaman, D.P.,Insausti, S.,Carravilla, P.,Garcia-Porras, M.,Largo, E.,Morillo, I.,Sanchez-Eugenia, R.,Zhang, L.,Cui, H.,Iloro, I.,Elortza, F.,Julien, J.P.,Eggeling, C.,Zwick, M.B.,Caaveiro, J.M.M.,Nieva, J.L. Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24:102987-102987, 2021 Cited by PubMed: 34505005DOI: 10.1016/j.isci.2021.102987 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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