1TL9
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![BU of 1tl9 by Molmil](/molmil-images/mine/1tl9) | High resolution crystal structure of calpain I protease core in complex with leupeptin | 分子名称: | CALCIUM ION, Calpain 1, large [catalytic] subunit, ... | 著者 | Moldoveanu, T, Campbell, R.L, Cuerrier, D, Davies, P.L. | 登録日 | 2004-06-09 | 公開日 | 2004-11-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site J.Mol.Biol., 343, 2004
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1TLO
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![BU of 1tlo by Molmil](/molmil-images/mine/1tlo) | High resolution crystal structure of calpain I protease core in complex with E64 | 分子名称: | CALCIUM ION, Calpain 1, large [catalytic] subunit, ... | 著者 | Moldoveanu, T, Campbell, R.L, Cuerrier, D, Davies, P.L. | 登録日 | 2004-06-09 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site J.Mol.Biol., 343, 2004
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3DF0
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![BU of 3df0 by Molmil](/molmil-images/mine/3df0) | Calcium-dependent complex between m-calpain and calpastatin | 分子名称: | CALCIUM ION, Calpain small subunit 1, Calpain-2 catalytic subunit, ... | 著者 | Moldoveanu, T, Gehring, K, Green, D.R. | 登録日 | 2008-06-11 | 公開日 | 2008-11-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature, 456, 2008
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2IMT
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![BU of 2imt by Molmil](/molmil-images/mine/2imt) | The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site | 分子名称: | Apoptosis regulator BAK, ZINC ION | 著者 | Moldoveanu, T, Liu, Q, Tocilj, A, Watson, M, Shore, G.C, Gehring, K.B. | 登録日 | 2006-10-04 | 公開日 | 2007-01-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol.Cell, 24, 2006
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1MDW
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![BU of 1mdw by Molmil](/molmil-images/mine/1mdw) | Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation | 分子名称: | CALCIUM ION, Calpain II, catalytic subunit | 著者 | Moldoveanu, T, Hosfield, C.M, Lim, D, Jia, Z, Davies, P.L. | 登録日 | 2002-08-07 | 公開日 | 2003-04-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Calpain silencing by a reversible intrinsic mechanism. Nat.Struct.Biol., 10, 2003
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1KXR
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![BU of 1kxr by Molmil](/molmil-images/mine/1kxr) | Crystal Structure of Calcium-Bound Protease Core of Calpain I | 分子名称: | CALCIUM ION, thiol protease DOMAINS I AND II | 著者 | Moldoveanu, T, Hosfield, C.M, Lim, D, Elce, J.S, Jia, Z, Davies, P.L. | 登録日 | 2002-02-01 | 公開日 | 2002-03-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | A Ca(2+) switch aligns the active site of calpain. Cell(Cambridge,Mass.), 108, 2002
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2M5B
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![BU of 2m5b by Molmil](/molmil-images/mine/2m5b) | The NMR structure of the BID-BAK complex | 分子名称: | Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB | 著者 | Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R. | 登録日 | 2013-02-19 | 公開日 | 2013-04-17 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | BID-induced structural changes in BAK promote apoptosis. Nat.Struct.Mol.Biol., 20, 2013
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2IMS
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![BU of 2ims by Molmil](/molmil-images/mine/2ims) | The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site | 分子名称: | Apoptosis regulator BAK, ZINC ION | 著者 | Moldoveanu, T, Liu, Q, Tocilj, A, Watson, M, Shore, G.C, Gehring, K.B. | 登録日 | 2006-10-04 | 公開日 | 2006-12-26 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site Mol.Cell, 24, 2006
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6D74
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![BU of 6d74 by Molmil](/molmil-images/mine/6d74) | |
6CKV
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![BU of 6ckv by Molmil](/molmil-images/mine/6ckv) | |
7M5B
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![BU of 7m5b by Molmil](/molmil-images/mine/7m5b) | |
7M5C
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![BU of 7m5c by Molmil](/molmil-images/mine/7m5c) | |
7M5A
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![BU of 7m5a by Molmil](/molmil-images/mine/7m5a) | |
2G8J
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![BU of 2g8j by Molmil](/molmil-images/mine/2g8j) | Calpain 1 proteolytic core in complex with SNJ-1945, a alpha-ketoamide-type inhibitor. | 分子名称: | ((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-DIOXOPROPYL)AMINO)CARBONYL)-3-METHYLBUTYL)CARBAMIC ACID 5-METHOXY-3-OXAPENTYL ESTER, CALCIUM ION, Calpain-1 catalytic subunit | 著者 | Cuerrier, D, Moldoveanu, T, Davies, P.L, Campbell, R.L. | 登録日 | 2006-03-02 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45, 2006
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2G8E
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![BU of 2g8e by Molmil](/molmil-images/mine/2g8e) | Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Calpain-1 catalytic subunit, ... | 著者 | Cuerrier, D, Moldoveanu, T, Davies, P.L, Campbell, R.L. | 登録日 | 2006-03-02 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45, 2006
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2KBW
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![BU of 2kbw by Molmil](/molmil-images/mine/2kbw) | Solution Structure of human Mcl-1 complexed with human Bid_BH3 peptide | 分子名称: | BH3-interacting domain death agonist, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Liu, Q, Moldoveanu, T, Sprules, T, Matta-Camacho, E, Mansur-Azzam, N, Gehring, K. | 登録日 | 2008-12-09 | 公開日 | 2009-12-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Apoptotic regulation by MCL-1 through heterodimerization. J.Biol.Chem., 285, 2010
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2NQI
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![BU of 2nqi by Molmil](/molmil-images/mine/2nqi) | Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor. | 分子名称: | CALCIUM ION, Calpain-1 catalytic subunit, N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}PENT-4-ENOYL]-L-ARGINYL-L-TRYPTOPHANAMIDE | 著者 | Cuerrier, D, Davies, P.L, Campbell, R.L, Moldoveanu, T. | 登録日 | 2006-10-31 | 公開日 | 2007-01-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282, 2007
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2NQG
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![BU of 2nqg by Molmil](/molmil-images/mine/2nqg) | Calpain 1 proteolytic core inactivated by WR18(S,S), an epoxysuccinyl-type inhibitor. | 分子名称: | 5-AZANYLIDYNE-N-[(2S)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]-L-NORVALYL-L-ARGINYL-L-TRYPTOPHANAMIDE, CALCIUM ION, Calpain-1 catalytic subunit | 著者 | Cuerrier, D, Davies, P.L, Campbell, R.L, Moldoveanu, T. | 登録日 | 2006-10-31 | 公開日 | 2007-01-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282, 2007
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1ZY3
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![BU of 1zy3 by Molmil](/molmil-images/mine/1zy3) | |
2OO9
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![BU of 2oo9 by Molmil](/molmil-images/mine/2oo9) | |