2G8J
Calpain 1 proteolytic core in complex with SNJ-1945, a alpha-ketoamide-type inhibitor.
Summary for 2G8J
| Entry DOI | 10.2210/pdb2g8j/pdb |
| Related | 1KXR 1TL9 1TLO 1ZCM 2G8E |
| Descriptor | Calpain-1 catalytic subunit, CALCIUM ION, ((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-DIOXOPROPYL)AMINO)CARBONYL)-3-METHYLBUTYL)CARBAMIC ACID 5-METHOXY-3-OXAPENTYL ESTER, ... (4 entities in total) |
| Functional Keywords | protease, peptidase, inhibitor, alpha-ketoamide, hydrolase |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Cytoplasm : P97571 |
| Total number of polymer chains | 1 |
| Total formula weight | 39376.28 |
| Authors | Cuerrier, D.,Moldoveanu, T.,Davies, P.L.,Campbell, R.L. (deposition date: 2006-03-02, release date: 2006-06-06, Last modification date: 2023-08-30) |
| Primary citation | Cuerrier, D.,Moldoveanu, T.,Inoue, J.,Davies, P.L.,Campbell, R.L. Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45:7446-7452, 2006 Cited by PubMed: 16768440DOI: 10.1021/bi060425j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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