2NQI
Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor.
Summary for 2NQI
Entry DOI | 10.2210/pdb2nqi/pdb |
Related | 1KXR 1TL9 1TLO 2G8E 2G8J 2NQG |
Descriptor | Calpain-1 catalytic subunit, CALCIUM ION, N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}PENT-4-ENOYL]-L-ARGINYL-L-TRYPTOPHANAMIDE, ... (4 entities in total) |
Functional Keywords | epoxide, epoxysuccinyl, protease, peptidase, proteinase, inactivator, inhibitor, hydrolase |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Cytoplasm : P97571 |
Total number of polymer chains | 1 |
Total formula weight | 39485.37 |
Authors | Cuerrier, D.,Davies, P.L.,Campbell, R.L.,Moldoveanu, T. (deposition date: 2006-10-31, release date: 2007-01-09, Last modification date: 2023-08-30) |
Primary citation | Cuerrier, D.,Moldoveanu, T.,Campbell, R.L.,Kelly, J.,Yoruk, B.,Verhelst, S.H.L.,Greenbaum, D.,Bogyo, M.,Davies, P.L. Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282:9600-9611, 2007 Cited by PubMed: 17218315DOI: 10.1074/jbc.M610372200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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