1TL9

High resolution crystal structure of calpain I protease core in complex with leupeptin

Summary for 1TL9

• Entry DOI: 10.2210/pdb1tl9/pdb
• Related: 1DFO 1KFU 1KFX 1KXR 1MDW 1NX0 1TLO
• Related PRD ID: PRD_000216
• Descriptor: Calpain 1, large [catalytic] subunit, leupeptin inhibitor, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: covalently-linked inhibitor at the active site cysteine forms a hemithioacetal, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cytoplasm (By similarity): P97571
• Total number of polymer chains: 2
• Total formula weight: 39314.29

Authors

Moldoveanu, T.,Campbell, R.L.,Cuerrier, D.,Davies, P.L. (deposition date: 2004-06-09, release date: 2004-11-02, Last modification date: 2024-04-03)

• Primary citation: Moldoveanu, T.,Campbell, R.L.,Cuerrier, D.,Davies, P.L.; Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site; J.Mol.Biol., 343:1313-1326, 2004; PubMed: 15491615; DOI: 10.1016/j.jmb.2004.09.016

Experimental method

X-RAY DIFFRACTION (1.8 Å)