2G8E
Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor
Summary for 2G8E
| Entry DOI | 10.2210/pdb2g8e/pdb |
| Related | 1KXR 1TL9 1TLO 1ZCM 2G8J |
| Descriptor | Calpain-1 catalytic subunit, CALCIUM ION, N-[(2S)-1,4-dihydroxybutan-2-yl]-N~2~-(phenylcarbamothioyl)-L-leucinamide, ... (5 entities in total) |
| Functional Keywords | protease, peptidase, inhibitor, cyclic hemiacetal, aldehyde, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Rattus norvegicus (Norway rat) |
| Cellular location | Cytoplasm : P97571 |
| Total number of polymer chains | 1 |
| Total formula weight | 39433.42 |
| Authors | Cuerrier, D.,Moldoveanu, T.,Davies, P.L.,Campbell, R.L. (deposition date: 2006-03-02, release date: 2006-06-06, Last modification date: 2023-08-30) |
| Primary citation | Cuerrier, D.,Moldoveanu, T.,Inoue, J.,Davies, P.L.,Campbell, R.L. Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography Biochemistry, 45:7446-7452, 2006 Cited by PubMed: 16768440DOI: 10.1021/bi060425j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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