3DF0

Calcium-dependent complex between m-calpain and calpastatin

Summary for 3DF0

Entry DOI	10.2210/pdb3df0/pdb
Descriptor	Calpain-2 catalytic subunit, Calpain small subunit 1, Calpastatin, ... (4 entities in total)
Functional Keywords	protease core domain, penta ef-hand domains, c2-like domain, inhibitor loop-out, hydrolase, membrane, protease, thiol protease, phosphoprotein, protease inhibitor, thiol protease inhibitor
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm : Q07009 Q64537
Total number of polymer chains	3
Total formula weight	112562.88
Authors	Moldoveanu, T.,Gehring, K.,Green, D.R. (deposition date: 2008-06-11, release date: 2008-11-11, Last modification date: 2023-08-30)
Primary citation	Moldoveanu, T.,Gehring, K.,Green, D.R. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature, 456:404-408, 2008 Cited by PubMed: 19020622 DOI: 10.1038/nature07353 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation