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7UMB
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BU of 7umb by Molmil
NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Marsiglia, W.M, Khan, K.M, Dar, A.C.
登録日2022-04-06
公開日2023-09-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.231 Å)
主引用文献Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.
Nat.Chem.Biol., 20, 2024
8UOZ
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BU of 8uoz by Molmil
EmrE structure in the TPP-bound state (WT/E14Q heterodimer)
分子名称: SMR family multidrug efflux protein EmrE, TETRAPHENYLPHOSPHONIUM
著者Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J.
登録日2023-10-20
公開日2024-05-29
最終更新日2024-07-03
実験手法SOLID-STATE NMR, SOLUTION NMR
主引用文献Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Nat Commun, 15, 2024
8UWU
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BU of 8uwu by Molmil
EmrE structure in the proton-bound state (WT/L51I heterodimer)
分子名称: SMR family multidrug efflux protein EmrE
著者Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J.
登録日2023-11-08
公開日2024-05-29
最終更新日2024-07-03
実験手法SOLID-STATE NMR, SOLUTION NMR
主引用文献Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Nat Commun, 15, 2024
6PNX
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BU of 6pnx by Molmil
Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction
分子名称: Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Mohammadi, M.
登録日2019-07-03
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.
Nat.Chem.Biol., 16, 2020
5EG3
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BU of 5eg3 by Molmil
Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
著者Huang, Z, Li, X, Mohammadi, M.
登録日2015-10-26
公開日2016-02-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.606 Å)
主引用文献Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.
Mol.Cell, 61, 2016
5UI0
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BU of 5ui0 by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation
分子名称: CITRATE ANION, Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-12
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UHN
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BU of 5uhn by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-11
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.909 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UGX
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BU of 5ugx by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-10
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UGL
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BU of 5ugl by Molmil
Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation
分子名称: Fibroblast growth factor receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION
著者Mohammadi, M, Chen, H.
登録日2017-01-09
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.861 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
6D1V
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BU of 6d1v by Molmil
Crystal structure of E. coli RppH-DapF complex, monomer bound to RNA
分子名称: CHLORIDE ION, Diaminopimelate epimerase, GLYCEROL, ...
著者Gao, A, Serganov, A.
登録日2018-04-12
公開日2018-05-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
6D1Q
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BU of 6d1q by Molmil
Crystal structure of E. coli RppH-DapF complex, monomer
分子名称: CHLORIDE ION, Diaminopimelate epimerase, GLYCEROL, ...
著者Gao, A, Serganov, A.
登録日2018-04-12
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
6D13
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BU of 6d13 by Molmil
Crystal structure of E.coli RppH-DapF complex
分子名称: CHLORIDE ION, Diaminopimelate epimerase, IODIDE ION, ...
著者Gao, A, Serganov, A.
登録日2018-04-11
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
7JUQ
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BU of 7juq by Molmil
Crystal Structure of KSR2:MEK1 in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUR
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BU of 7jur by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUX
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BU of 7jux by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUV
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BU of 7juv by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C, Scopton, A.P.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUT
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BU of 7jut by Molmil
Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib
分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUS
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BU of 7jus by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib
分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JV0
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BU of 7jv0 by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.63 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUW
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BU of 7juw by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JV1
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BU of 7jv1 by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C, Scopton, A.P.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUZ
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BU of 7juz by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Selumetinib
分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUU
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BU of 7juu by Molmil
Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-09-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020
7JUY
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BU of 7juy by Molmil
Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ...
著者Khan, Z.M, Dar, A.C.
登録日2020-08-20
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.096 Å)
主引用文献Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature, 588, 2020

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