7UMB

NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex

Summary for 7UMB

• Entry DOI: 10.2210/pdb7umb/pdb
• Descriptor: Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: tracer, kinase, complex, mek1, ksr2, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 84924.13

Authors

Marsiglia, W.M.,Khan, K.M.,Dar, A.C. (deposition date: 2022-04-06, release date: 2023-09-27, Last modification date: 2024-03-20)

• Primary citation: Marsiglia, W.M.,Chow, A.,Khan, Z.M.,He, L.,Dar, A.C.; Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.; Nat.Chem.Biol., 20:373-381, 2024; PubMed: 37919548; DOI: 10.1038/s41589-023-01454-8

Experimental method

X-RAY DIFFRACTION (3.231 Å)